Characterizing cognition across the lifespan in untreated psychosis in China

 描述（由申请人提供）：我们建议利用一个独特的机会来研究认知及其与精神病患者（IWP）的大型未经治疗样本中其他领域的关系，在伦理上适当的背景下，不太可能继续提供。精神病发作后，在治疗IWP的认知研究表明，在许多SCZ患者的持续赤字，这些都存在于双相情感性精神病在一定程度上较小，表明精神病的严重程度的连续性。为了解决这一问题，我们建议在宁夏省内进行大样本（n=500）的完全未经治疗的IWP，AP治疗前进行评估，年龄范围很广（21至65岁），并进行社区抽样。宁夏是中国最贫困和偏远的省份之一，686计划尚未完全渗透，但未经治疗的病例正在增加。还将招募接受治疗的IWP的社区抽样对照组（n=500）（在地点、性别、年龄和疾病持续时间方面匹配）。我们的目标是阐明认知的自然过程及其与症状和功能的关系，在没有药物作用的情况下。我们在686国民待遇计划中拥有前所未有的机会。我们的多学科研究团队由来自流行病学，临床心理学和精神病学领域的世界公认的专家组成。在成功合作的历史基础上，每位研究员都带来了广泛的能力建设经验，以执行这一具有挑战性的项目。另一个主要目标是在宁夏省培训一批新的研究人员，以提高对未经治疗的精神病进行干预的能力，从而成为686计划扩大规模的典范。

 DESCRIPTION (provided by applicant): We propose to take advantage of a unique opportunity to study cognition and its relation to other domains in a large untreated sample of individuals with psychosis (IWP), within an ethically appropriate context that is unlikely to continue to be available. After the onset of psychosis, studies of cognition in treated IWP suggest persisting deficits in many SCZ patients; these are present in bipolar affective psychoses to a somewhat lesser extent, indicating a continuum of severity in psychosis. To address this, we propose to study cognition among a large sample (n=500) of completely untreated IWP, assessed prior to AP treatment, within Ningxia Province who span a wide age range (21 to 65) and are community sampled. Ningxia is among the most poor and remote provinces in China, where the 686 Program has not fully penetrated but where identification of untreated cases is increasing. A community sampled comparison group of treated IWP's (n=500) (matched on locale, gender, age, and duration of illness) will also be recruited. Our goal is to illuminate the natural course of cognition and its relation to symptoms and functioning, in the absence of medication effects. We possess an unprecedented opportunity to do so within the 686 national treatment program. Our multidisciplinary research team is comprised of world-recognized experts from the fields of epidemiology, clinical psychology, and psychiatry. Building upon a history of successful collaborations, each investigator brings extensive capacity-building experience to execute this challenging project. A major goal is also to train a new cohort of investigators in Ningxia Province to increase capacity to intervene with untreated psychosis, thus serving as a model for scale-up for the 686 program.