Administrative Core

这项研究项目名为变革性T细胞应答的OMICS签名 针对艾滋病毒的治疗性疫苗接种(省略艾滋病毒)将使用来自人类临床试验的样本和 协同的非人类灵长类动物研究，以询问治疗性艾滋病毒疫苗如何最好地诱导有效的T- 来自慢性感染和抗原暴露的宿主免疫系统的细胞反应。该计划 具有很强的多学科和国际化特征，由一支由以下人员组成的专家PI团队建立 长期的合作者，并有机会获得独特的人类队列和新的治疗方法 为非人类灵长类动物接种疫苗。这种多样性，包括地理多样性，需要强大的 行政结构，以促进方案要素之间的协同作用， 结构化沟通。这一行政核心将为 计划项目，履行行政职能，与NIH/NIAID工作人员沟通，促进 项目和数据管理和分析核心，鼓励其科学家提出批评和建议 和伊萨，促进财政责任，并确保项目的持续卓越及其能力 解决具体目标。 行政核心将设在加州大学戴维斯分校，由哈蒂根-奥康纳博士领导，他是该项目的两名成员之一 MPI。哈蒂根-奥康纳博士此前曾领导加州大学戴维斯分校退休艾滋病毒P01的行政核心， 它雇用了许多相同的人员，并履行了类似的职能。他也是The Large的联席PI U42拨款资助美国国立卫生研究院体细胞基因组编辑非人灵长类检测中心 财团。因此，Hartigan-O‘Connor博士在管理大型合作伙伴方面拥有丰富的经验 像这样的项目。核心的组织由管理员、专家、外部 科学咨询委员会和内部指导委员会。 行政核心的具体目标是： 1.提供组织和方案结构，以促进科学的卓越。 2.提供组织和财务监督以及未来规划，建立决策流程，制定 优先顺序，并解决争端 3.确保高效的数据、信息和资源共享。

This Research Program Project, titled Omics signatures of transformative T-cell responses to therapeutic vaccination against HIV (OmiT-HIV), will use samples from human clinical trials and synergistic non-human primate studies to ask how therapeutic HIV vaccines can best elicit effective T- cell responses from the chronically infected and antigen-exposed host immune system. The Program has a strong multidisciplinary and international character, established by a team of expert PIs who are longstanding collaborators and have access to unique human cohorts and novel approaches to therapeutic vaccination of non-human primates. Such diversity, including geographic diversity, requires a strong administrative structure to promote synergy between the programmatic elements by facilitating regular, structured communication. This Administrative Core will provide overall organizational structure for the Program Project, perform administrative functions, interface with NIH/NIAID staff, foster cooperation between projects and with the Data Management and Analysis Core, encourage criticism and advice from its scientists and ESAB, promote fiscal responsibility, and assure the continued excellence of the Project and its ability to address the Specific Aims. The Administrative Core will be based at UC Davis and led by Dr. Hartigan-O’Connor, one of the project’s two MPIs. Dr. Hartigan-O’Connor previously led the administrative core for the RETIRE-HIV P01 at UC Davis, which engaged many of the same personnel and performed similar functions. He is also co-PI of the large U42 grant funding the Nonhuman Primate Testing Center for the NIH’s Somatic Cell Genome Editing Consortium. Thus, Dr. Hartigan-O’Connor has abundant experience in management of large collaborative projects such as this. The Core’s organization is supplemented by administrators, specialists, the External Scientific Advisory Board, and an Internal Steering Committee. The specific aims of the Administrative Core are: 1. Provide an organizational and programmatic structure to promote scientific excellence. 2. Provide organizational and financial oversight and future planning, establish decision-making processes, set priorities, and resolve disputes 3. Ensure efficient data, information, and resource sharing.