Institutional Career Development Core

了解唐氏综合征的终生共病调查（包括） 补充将支持一个有前途的早期职业调查员，汉娜雷亚，以扩大她的研究， 与唐氏综合征同时发生的行为和认知障碍的相关临床经验。中 最常见的，生活质量损害，和研究不足的行为表型与唐氏症 综合征是具有挑战性的行为，如攻击或不服从。这些行为 对唐氏综合征患者及其家庭的长期负面影响，包括 对全球运作和独立性至关重要的技能的获得减少。拟议 该项目旨在识别和分析儿童挑战行为的风险因素的相互作用 唐氏综合症，这将为干预提供信息。 这个项目将调查非语言和语言智商作为挑战性行为严重程度的预测因子， 在120名6至14岁的唐氏综合征儿童中进行了执行功能的调节。可行性 将对10个唐氏综合征儿童家庭和5个成人进行措施和可接受性评估 唐氏综合征和潜在的建模和多模式的措施将用于操作EF， 挑战行为。同样的模型将在自闭症儿童的档案样本中进行调查 谱系障碍（ASD），一种在常见的共同发生的病症中重叠并发生在 唐氏综合症儿童的患病率升高。档案样本包括患有已知 与ASD伴（n=125）或不伴（n=87）智力残疾和DYRK1A相关的遗传病因学 突变，唐氏综合征的候选基因（n=27），年龄3至24岁。与ASD的比较将告知 现有的ASD儿童循证干预措施是否适用于唐氏症儿童 综合征 Rea博士将加入转化健康科学研究所（位于华盛顿大学） 作为KL2学者，并接受大学高素质的高级调查员团队的指导 华盛顿，西雅图儿童医院，和加州大学戴维斯精神研究所。通过 KL2计划，Rea博士将通过互动教学获得转化科学的知识和技能 与多学科KL2队列的会议。此外，Rea博士将寻求研究方面的强化培训， 唐氏综合征患儿及其家属，电生理方法与儿童， 结构方程模型的统计训练。拟议的机制将支持她的进展 建立自己的实验室，并申请独立的研究基金，以支持未来的研究。 一项调查唐氏症儿童挑战行为轨迹和干预措施的临床试验 综合征

The INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndrome (INCLUDE) supplement will support a promising early career investigator, Hannah Rea, to broaden her research and related clinical experience in behavioral and cognitive disorders co-occurring with Down syndrome. Among the most common, quality-of-life impairing, and understudied behavioral phenotypes associated with Down syndrome are challenging behaviors, such as aggression or noncompliance. Challenging behaviors have negative long-term consequences for individuals with Down syndrome and their families, including contributing to decreased acquisition of skills that are critical for global functioning and independence. The proposed project aims to identify and analyze the interacting effects of risk factors for challenging behaviors in children with Down syndrome, which will inform interventions. This project will investigate nonverbal and verbal IQ as predictors of severity of challenging behaviors, moderated by executive functioning in 120 children with Down syndrome ages 6 to 14 years. The feasibility and acceptability of measures will be assessed with 10 families of children with Down syndrome and 5 adults with Down syndrome and latent modeling and multi-modal measures will be used to operationalize EF and challenging behaviors. The same models will be investigated in an archival sample of children with autism spectrum disorder (ASD), a disorder that overlaps in commonly co-occurring conditions and occurs in heightened prevalence in children with Down syndrome. The archival sample includes children with a known genetic etiology associated with ASD with (n=125) or without (n=87) intellectual disability, and with a DYRK1A mutation, a candidate gene for Down syndrome (n=27), ages 3 to 24 years. The comparison to ASD will inform whether existing evidence-based interventions for children with ASD may be adapted for children with Down syndrome. Dr. Rea will join the Institute of Translational Health Sciences (based at the University of Washington) as a KL2 scholar and receive mentorship from a highly qualified team of senior investigators at the University of Washington, Seattle Children’s Hospital, and the University of California, Davis MIND Institute. Through the KL2 program, Dr. Rea will gain knowledge and skills in translational science through interactive didactic sessions with the multidisciplinary KL2 cohort. Additionally, Dr. Rea will seek intensive training in research with children with Down syndrome and their families, electrophysiology methods with children, and advanced statistical training in structural equation modeling. The proposed mechanism will support her progression towards establishing her own laboratory and applying for independent research funding to support a future clinical trial investigating the trajectory of and interventions for challenging behaviors in children with Down syndrome.