课题基金 / 基金详情

Immune suppressor mechanisms in patients with GI cancer

Immune suppressor mechanisms in patients with GI cancer
胃肠道癌症患者的免疫抑制机制
批准号：
10014628
负责人：
Tim Greten
金额：
$10.58万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10014628
关键词：
CellsCellular biologyCorrelative StudyFlow CytometryGene Expression ProfilingImmuneImmunotherapyMalignant NeoplasmsMalignant neoplasm of gastrointestinal tractManuscriptsMyeloid-derived suppressor cellsPatientsPeripheral Blood Mononuclear CellPublishingSamplingT-LymphocyteTumor ImmunityWorkanti-CTLA4basenovel strategiestumor

项目摘要

项目成果

Tim Greten的其他基金

相似基金

相关文献

中文摘要
翻译
免疫疗法的一个主要问题是，我们不明白为什么有些疗法对病人有效，而另一些却失败了。我们使用来自接受抗ctla4 +局部治疗的患者的样本，以更好地了解基于免疫的方法在HCC中的作用。我们正在研究来自患者的肿瘤样本，使用基因表达分析并对PBMC进行流式细胞术研究。这些研究正在进行中。到目前为止，我们已经能够证明肿瘤浸润性T细胞患者更有可能对抗ctla4 +局部治疗有反应。我们最近发表了一篇描述NCI-C0120相关研究的手稿。
英文摘要
One of the major problems in immune therapy is that we do not understand why some treatments work and others fail in patients. We use samples from patients treated with anti-CTLA4 plus locoregional therapy to better understand how immune based approaches work in HCC. We are studying tumor samples from patients on our studies using gene expression analysis and perform flow cytometry studies on PBMC. These studies are ongoing. So far, we have been able to demonstrate that patients with tumor infiltrating T cells are more likely to respond to anti-CTLA4 plus locoregional therapy. We have recently published a manuscript describing correlative studies for NCI-C0120.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Center for Cell-based Therapy - Cures
Immune suppressor mechanism in a murine model of hepatitis and liver cancer
Immune suppressor mechanisms in patients with GI cancer
Clinical protocols for the treatment of gastrointestinal cancer
海外基金