Signal Processing And Instrumentation Section

信号处理和仪器部分（SPIS）的研究和开发活动是与NIH研究所科学家的合作努力，需要开发生物医学实验室和临床研究系统，仪器和方法。这些合作中的大多数都需要新的方法和设计，而这些方法和设计只有最低限度的既定标准或技术知识。SPIS的员工在工程研发的各个阶段都拥有丰富的技术经验。SPIS的工作人员与他们的合作者一起审查临床和生物医学科学，以制定项目规范。SPIS的工作人员评估理论和实践的限制，考虑商业上可用的技术，并最终提出各种解决方案。SPIS的职责通常继续与动手设计，实施，测试，安装，培训，文档和定制研究系统或方法的生产。目前的合作项目以及相关的研究包括： 1. 改良经尿道切除装置。 2. 用于球状体生长和组织学的组织培养基质铸型。 3. 使用人腹膜的人间皮瘤表面原发性和转移性癌的离体模型; NCI。 4. 具有光谱聚焦汽车和受激发射的多模态非线性显微术。 5. 小鼠运动和运动稳定性受化学发生刺激影响的视频采集。 6. 严重认知障碍个体认知测试新框架的评价。 7. 用于人源化骨模型研究的静电纺丝支架的设计和制造。 8. 用于学习和记忆的家庭笼鼠监测装置。 9. 用于疾病和正常状态分子分析的组织显微切割（LCM、TAM、xMD、TAM、fTAM）; NICHD、NIDA、NIBIB、NCI、NIMH。 10. 与癌症治疗研究相关的体内氧状态的电子顺磁共振成像; NCI，NINDS。 11. 用于疼痛相关小鼠行为自动检测的视频监控系统。 12. 果蝇的高通量视频评估-药物疗效和睡眠研究; NHLBI，NIDDK。 13. 基于PNA的HIV-1分子诊断的微流体平台; NIDDK，NIBIB。 14. 使用非线性光学技术的活体显微术。 15. 运动障碍常规临床评估的视频跟踪系统; NIDA，NIA。 16. 电场对细胞的影响-作为癌症治疗的评价; NICHD，NIBIB。 17. 高通量系统，以评估药物/化学品在成年苍蝇; NIDDK。 18. 用于成像、诊断和病理学研究的前列腺切除术标本整体切片的先进方法-使用个体化MR模型的体内前列腺MRI和组织学相关性; NCI。 19. 体感神经元反应仪器。 20. 前列腺癌定位的多特征框架。 21. 前列腺肿瘤新鲜组织引导采购方法。 22. 用于表型分析和癌症治疗评价的笼舍环境中啮齿动物连续观察系统（SCORHE）; NCI、NIDDK、NHLBI、NIEHS、FDA。 23. 带传感器的小鼠家庭环境监测; NIDDK、OD、FDA、HHS。 24. 用于疾病检测和监测的定量荧光寿命成像; NICHD，NCI，NIBIB。 25. 用于癌细胞培养的血管模拟物; NCI，NIBIB。 26. OCT和自适应光学视网膜成像与眼动追踪。 27. 用于视网膜营养不良研究的小鼠照明系统。 28. PRiME -心血管介入; NHLBI，CNMC。 29. 利用光片显微镜了解果蝇中诱发运动序列的产生。 30. 通过生物反应器和3D凝胶工程视网膜治疗; NEI，NIBIB。 31. 蛋白质组装动力学分析超浓缩。 32. C.时间SPIM图像中的雅丽鱼胚胎跟踪; NIBIB。 33. 骨生长板软骨颗粒培养生物反应器。 34. 啮齿动物前庭感觉诱发电位研究技术。 35. 正常和疾病脑组织的定量表征; NICHD，NHLBI。 36. 放射化学实验室仪器和自动化使放射性示踪剂的开发和临床前神经成像研究。 37. 造血干细胞骨髓生物反应器; NHLBI，NIBIB。 38. 用于非现场肿瘤成像的便携式荧光照相机系统; NCI，NIBIB。 39. 基于图像的机器人靶向系统，用于控制活体生物组织（脑/脊髓）研究的显微操作器。 40. 近红外光谱法胎盘实时血氧测定。 41. 畸变产物耳声发射系统。 42. 用于神经元回路研究的鼠须监测。 43. 下一代电休克治疗系统。 44. 用于分子分析和生物医学研究的微流体、微加工和微分析技术。 45. 类扁桃体器官三维组织培养生物反应器。

The research and development activities of the Signal Processing and Instrumentation Section (SPIS) are collaborative efforts with NIH Institute scientists that require the development of biomedical laboratory and clinical research systems, instrumentation, and methodologies. The majority of these collaborations require novel approaches and designs for which there are minimal established criteria or technical knowledge. SPIS staff have in-depth technical experience in all phases of engineering research and development. With their collaborators, SPIS staff review the clinical and biomedical sciences to formulate project specifications. SPIS staff evaluate the theoretical and practical constraints, consider commercially available technologies, and finally propose various solutions. SPIS responsibilities often continue with the hands-on design, implementation, testing, installation, training, documentation, and production of a custom research system or methodology. Current collaborative projects, as well as associated research studies include: 1. Improved Transurethral Resection Device; NCI. 2. Tissue Culture Matrix Casting for Spheroid Growth and Histology; NCI. 3. Ex Vivo Model Using Human Peritoneum for Primary and Metastatic Cancer of Human Mesothelial Surfaces; NCI. 4. Multimodal Nonlinear Microscopy with Spectral-focusing CARS and Stimulated Emission; NHLBI. 5. Video Acquisition of Mouse Locomotion and Motor Stability when Impacted by Chemogenetic Stimulation; NINDS. 6. Evaluation of a Novel Cognitive Testing Framework for Individuals with Severe Cognitive Impairment; NIMH. 7. Design and Fabrication of Electrospun Scaffolds for the Study of Humanized Bone Models; NCI. 8. Home-cage Mouse Monitoring Device for Learning and Memory; NIDDK. 9. Tissue Microdissection for Molecular Analysis of Disease and Normal States (LCM, TAM, xMD, TAM, fTAM); NICHD, NIDA, NIBIB, NCI, NIMH. 10. Electron Paramagnetic Resonance Imaging of In Vivo Oxygen Status Associated with Cancer Treatment Studies; NCI, NINDS. 11. Video Monitoring System for Automated Detection of Pain Related Mice Behaviors; NIDDK. 12. High-throughput Video-based Assessment of Drosophila - Drug Efficacy & Sleep Studies; NHLBI, NIDDK. 13. Microfluidic Platform for PNA-Based Molecular Diagnostics of HIV-1; NIDDK, NIBIB. 14. Intra-vital Microscopy Using Non-linear Optical Techniques; NHLBI. 15. Video-Based Tracking System for the Routine Clinical Evaluation of Motor Disorders; NIDA, NIA. 16. Electric Field Effects on Cells - Evaluation as Cancer Therapy; NICHD, NIBIB. 17. High-throughput Systems to Evaluate Drug/Chemicals in Adult Flies; NIDDK. 18. Advanced Methods of Whole Mount Sectioning of Prostatectomy Specimens for Imaging, Diagnosis, and Pathology Studies - Correlating In Vivo Prostate MRI and Histopathology using Individualized MR-Based Molds; NCI. 19. Response of Somatosensory Neurons Instrumentation; NCCIH. 20. Multi-characteristic Framework for Prostate Cancer Localization; NCI. 21. Prostate Tumor Fresh Tissue Guided Procurement Methods; NCI. 22. System for Continuous Observation of Rodents in Home-cage Environment (SCORHE) for Phenotyping and Cancer Treatment Evaluation; NCI, NIDDK, NHLBI, NIEHS, FDA. 23. Mouse Homecage Environmental Monitoring with Sensors; NIDDK, OD, FDA, HHS. 24. Quantitative Fluorescence Lifetime Imaging for Disease Detection and Monitoring; NICHD, NCI, NIBIB. 25. Vessel Mimetics for Cancer Cell Culture; NCI, NIBIB. 26. OCT and Adaptive Optics Retinal Imaging with Eye Tracking; NEI. 27. Mouse Illumination System for Retinal Dystrophy Studies; NEI. 28. PRiME - Cardiovascular Intervention; NHLBI, CNMC. 29. Using Light-sheet Microscopy to Understand Evoked Motor Sequence Generation in Drosophila; NIMH. 30. Engineering Retinal Therapies via Bioreactors & 3D Gels; NEI, NIBIB. 31. Analytical Ultracentrifugation for Protein Assembly Dynamics; NIBIB. 32. C. Elegans Embryo Tracking in Temporal SPIM Images; NIBIB. 33. Bone Growth Plate Cartilage Pellet Culture Bioreactor; NICHD. 34. Technologies to Study Rodent Vestibular Sensory Evoked Potentials; NIDCD. 35. Quantitative Characterization of Normal and Disease Cervix Tissue; NICHD, NHLBI. 36. Radiochemistry Laboratory Instrumentation and Automation Enabling Radiotracer Development and Preclinical Neuroimaging Research; NIAAA. 37. Hematopoietic Stem Cell Bone Marrow Bioreactor; NHLBI, NIBIB. 38. Portable Fluorescence Camera System for Offsite Tumor Imaging; NCI, NIBIB. 39. Image-Based Robotic Targeting System to Control Micromanipulators for Living Biological Tissues (Brain/Spinal) Studies; NINDS. 40. Placenta Real-time Oximetry Using Near Infrared Spectroscopy; NICHD. 41. Distortion Product Otoacoustic Emissions System; NIDCD. 42. Mouse Whisker Monitoring for Neuronal Circuit Studies; NIMH. 43. Next Generation Electroconvulsive Therapy System; NIMH. 44. Microfluidics, Microfabrication, and Microanalysis Technologies for Molecular Analysis and Biomedical Research; NIBIB, NIST. 45. Lymphoid Organ 3D Tissue Culture Bioreactor; NIAID.