Imaging of fungal infections
Imaging of fungal infections
批准号:
10019282
负责人:
Dima A Hammoud
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
在我们的初步实验中,我们发现烟曲霉对~3H-L鼠李糖的摄取高于对14C-DG的摄取,而其余糖的保存率很低。我们的发现得到了L-鼠李糖在感染动物体内摄取的放射自显影阳性的支持。
我们合成了一种18F标记的L-鼠李糖,目前正在感染烟曲霉的动物以及对照和无菌炎症动物模型上进行测试。
我们还在研究其他潜在的用于曲霉和假丝酵母菌成像的配体。
英文摘要
In our preliminary experiments, we found that 3H-L-Rhamnose uptake in Aspergillus fumigatus is higher than uptake of 14C-DG while the rest of the sugars were very poorly retained. Our findings were supported with positive autoradiography for L-Rhamnose uptake in infected animals.
We synthesized an 18F labeled version of L-Rhamnose and are now testing it in animals infected with aspergillus fumigatus as well as controls and sterile inflammation animal models.
We are also investigating other potential ligands for imaging aspergillus as well as candida.
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Imaging of fungal infections
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批准号:10691778
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Molecular imaging of viral infections
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批准号:10253692
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Molecular imaging of viral infections
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批准号:10920173
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients
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批准号:10920172
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Molecular Imaging of neuroHIv using animals models of disease
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批准号:9348210
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Molecular Imaging of neuroHIv using animals models of disease
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批准号:10019972
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Molecular Imaging of neuroHIv using animals models of disease
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批准号:9557292
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Molecular imaging of viral infections
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批准号:10691767
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients
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批准号:10019963
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Imaging of fungal infections
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批准号:10248112
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients
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批准号:10487161
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Neurovascular MRI in the Assessment of HIV-Associated Neurocognitive Disorders
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批准号:8565404
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Molecular Imaging of neuroHIv using animals models of disease
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批准号:9795930
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients
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批准号:10691766
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Neurovascular MRI in the Assessment of HIV-Associated Neurocognitive Disorders
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批准号:8952910
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
Imaging of fungal infections
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批准号:10920177
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients
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批准号:10248887
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Dima A Hammoud
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依托单位:
海外基金