SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP

藤黄果提取物（GCE）被提名为测试的基础上，其广泛使用的饮食援助和缺乏足够的毒性数据。它是2016年美国第六畅销的膳食补充剂（Smith等人，2017年）。GCE是从Garcinia gummi-gutta（从Garcinia cambogia重新命名）水果的果皮制备的，含有GCE的产品作为无麻黄的饮食辅助剂销售。GCE的预期作用包括抑制食欲、抑制脂质合成和通过产热燃烧脂肪。通常，GCE作为减肥补充剂的使用是通过每天三次饭前服用的囊片，导致总剂量约为4，500 - 6，000 mg/天（对于60 kg的人，约为75-100 mg/kg/天）。由于推荐的GCE方案（每日3次，与食物一起）以及传统上使用藤黄属作为印度美食中的成分，因此选择给药饲料作为给药途径，而不是口服灌胃，口服灌胃通常与草药供试品一起使用，并提供每日推注剂量。

Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose.