Tumor Immunology

项目摘要 该培训计划的目的是为免疫学研究的博士后研究人员做好准备 这将使它们能够对癌症的预防、诊断和治疗产生重大影响。超过 在过去的十年里，免疫学领域在各个方面都有了前所未有的发现。 这些令人兴奋的进展使人们更好地理解了癌症如何逃避免疫系统， 如何操纵先天免疫和特异性免疫以产生抗肿瘤免疫应答。为了 将这些新知识转化为有效的癌症治疗方法，有必要培养新一代 精通免疫学最新概念的免疫学家。学员将参加一个 免疫学研究的密集计划的指导下完成的导师与专业知识， 免疫学的特定领域。这将使年轻的研究人员能够开展重点免疫学研究 并将其与重要的临床和科学问题联系起来。为了让他们彻底接触到 免疫学研究的基本原则，学员将参加精心设计的 由俄亥俄州州立大学综合癌症中心主办的课程、会议和会议计划 中心（OSUCCC）和免疫学项目。学员还将受益于大量接触有关 生物信息学、生物统计学、人类癌症遗传学、转化医学等学科， 实验治疗学，以及在拨款写作和负责任的研究行为的培训。学员 将介绍最先进的方法和科学技术。该计划将鼓励 具有基本科学背景的医生-科学家和受训人员的参与， 交流思想，激发求知欲，拓宽参与者的视野。一直 一直并将继续努力从代表性不足的群体中招募人员， 程序.成功完成这一跨学科的培训计划将促进发展的 培训生的科学研究技能，为免疫学研究职业生涯做准备， 对我国癌症患者健康需求的影响。事实上，所有25名前受训人员都继续 学术追求，并保持了预期的职业轨迹。这些前受训人员中有17人是 仍在从事肿瘤免疫学研究（其中10人在学术机构获得教职） 其他四人仍在接受医疗培训。自上次续会以来，三名来自代表性不足群体的受训人员 被招募到这个训练项目中

Project Summary The purpose of this training program is to prepare postdoctoral researchers for careers in immunologic research that will enable them to have a significant impact on the prevention, diagnosis and treatment of cancer. Over the past decade, the field of immunology has witnessed an unprecedented level of discovery on every front. These exciting advances have led to an improved understanding of how cancers evade the immune system and how innate and specific immunity can be manipulated to generate an anti-tumor immune response. In order to translate this new knowledge into effective treatments for cancer, it will be necessary to train a new generation of immunologists who are well versed in the most recent concepts in immunology. Trainees will engage in an intensive program of immunologic research under the guidance of an accomplished mentor with expertise in a specific area of immunology. This will permit the young investigator to develop a focused immunologic research question and relate it to important clinical and scientific problems. In order that they have thorough exposure to the principles underlying the conduct of immunologic research, trainees will participate in a carefully designed program of courses, conferences, and meetings sponsored by the Ohio State University Comprehensive Cancer Center (OSUCCC) and the Immunology Program. Trainees will also benefit from significant exposure to related disciplines such as bioinformatics, biostatistics, human cancer genetics, translational medicine, and experimental therapeutics, as well as training in grant writing and the responsible conduct of research. Trainees will be introduce to state of the art methodologies and scientific techniques. This program will encourage the participation of both physician-scientists and trainees with a basic science background in order to enhance the exchange of ideas, stimulate intellectual curiosity, and broaden the perspectives of the participants. There has been and will continue to be a concerted effort to recruit persons from under-represented groups into this program. Successful completion of this inter-disciplinary training program will foster the development of the trainee's scientific research skills in preparation for an immunologic research career that will have a positive impact on the health needs of our nation's cancer patients. Indeed, all 25 former trainees have continued with academic pursuits and have maintained the expected career trajectory. Seventeen of these former trainees are still involved in tumor immunology research (of which 10 have garnered staff positions at academic institutions) and four others remain in medical training. Since the last renewal, three trainees from under-represented groups were recruited to this training program.