课题基金 / 基金详情

Identification of inhibitors of Zika Protease (NS2B-NS3)

Identification of inhibitors of Zika Protease (NS2B-NS3)
寨卡蛋白酶 (NS2B-NS3) 抑制剂的鉴定
批准号：
10005788
负责人：
Anton Simeonov
金额：
$13.27万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10005788
关键词：
Biological AssayChemicalsCollaborationsDiseaseDisease OutbreaksExtramural ActivitiesGenomicsGoalsInformaticsLinkModelingPeptide HydrolasesPharmaceutical ChemistryPolyproteinsProcessProtease InhibitorResearchUnited States National Institutes of HealthValidationVirus InhibitorsWorkZika Virusdrug discoveryinhibitor/antagonistnervous system disordernovelscreeningsmall moleculesmall molecule inhibitorsmall molecule therapeuticstherapeutic development

项目摘要

项目成果

Anton Simeonov的其他基金

相似基金

相关文献

中文摘要
翻译
最近寨卡病毒（ZIKV）爆发的上升与严重的神经系统疾病有关。ZIKV依赖于NS 2B/NS 3蛋白酶的活性进行多蛋白加工，合作团队的目标是发现这种病毒蛋白酶的新型小分子抑制剂。 在此期间，NCGC和合作团队致力于优化和验证高通量NS 2B检测并进行初步筛选;目前正在对已识别的命中分子进行验证和表征。
英文摘要
The recent rise of Zika virus (ZIKV) outbreaks has been linked to severe neurological disorders. ZIKV relies on the activity of the NS2B/NS3 protease for polyprotein processing, and the collaborative team aims to uncover novel small molecule inhibitors of this viral protease. During this period, the NCGC and collaborative team worked to optimize and validate a high-throughput NS2B assay and conduct primary screening; validation and characterization of identified hit molecules is currently underway.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
PRKACA for Fibrolamellar hepatocellular carcinoma
MST/ITC studies on Vimentin DHA interaction
Disrupting Type IV secretion function to prevent virulence in the pathogenic bacterium Legionella pneumophila
High-throughput multiparametric drug screening method for 3D spheroids
海外基金