Applications of methods in collaborative science

与北卡罗来纳大学的一名学生合作(Bauer等人)我们使用一项基于家庭的设计，探索了与一氧化氮信号和一氧化碳相关的遗传变异与先兆子痫的关系。与北卡罗来纳大学一名学生(Mazul等人)合作的第二个项目涉及神经母细胞瘤，该项目使用病例及其母亲的遗传数据来观察维生素A和相关基因的联合作用。另一个项目(Wang等人)与空气污染和对可能由甲基化介导的炎症途径的影响有关。我们基于对上海健康学生的小组研究发现了短期影响(在24小时内)。另一篇相关的第二篇论文正在审查中，该论文基于环境水平的长期影响，使用了Sister研究的美国数据。今年发表了一些与Ann Steiners“怀孕的时间”相关的生殖流行病学研究，该研究基于维生素D对周期长度和卵巢储备的影响(Jukic等人)。另一篇关于维生素D对受精率影响的论文正在修改中。

In work collaborative with a student at UNC (Bauer, et al.) we explored genetic variants related to nitric oxide signaling and carbon monoxide in relation to preeclampsia, using a family-based design. A second project with a UNC student (Mazul, et al.), which concerned neuroblastoma, used genetic data from cases and their mothers to look at joint effects of vitamin A and related genes. Another project (Wang, et al.) had to do with air pollution and effects on inflammatory pathways that may be mediated by methylation. We found short-term effects (within 24 hours) based on a panel study of healthy students in Shanghai. A related second paper is undergoing review, which was based on long-term effects of ambient levels, using US data from the Sister Study. Some reproductive epidemiology related to Ann Steiners "Time to Conceive" study was published this year, based on effects of vitamin D on cycle length and ovarian reserved (Jukic, et al.). Another paper on effects of vitamin D on fecundability is now in revision.