The InChianti Study

InCHIANTI在两个研究中心进行：基安蒂的基安蒂的格雷夫（研究中心1; 11，709名居民; 19.3% > 65岁;位于农村地区中部）和巴尼奥阿里波利（Antella村，研究中心2，4，704名居民; 20.3% > 65岁;紧邻佛罗伦萨市区）。为了获得两个具有代表性的人口样本，在两个地点中的每一个都使用了相同的两阶段抽样程序。 对于基线队列，1998年8月，从两个地点的人口登记处随机抽取了1270名65岁或以上的随机样本。 另外29名受试者是在90岁或以上的人群中随机选择的，直到该年龄组的至少30名男性和30名女性被纳入样本。 最后，从20-29岁、30-39岁、40-49岁、50-59岁和60-64岁的年龄层中随机抽样的男性和女性被依次邀请参加研究，直到20 - 59岁的每十年至少有30名男性和30名女性，60 - 64岁的15名男性和15名女性被招募。 这项研究的一个总体假设是，大多数人有行走障碍的限制，在一个或多个六个生理子系统，这些子系统的临床评价可以在规划治疗和预防干预措施是有价值的。 这些子系统包括：1）骨骼和关节; 2）肌肉; 3）中枢神经系统; 4）外周神经系统; 5）感知系统;以及6）能量产生和递送。 除了在检查期间进行的临床评估外，通过NIA的资助和与外部研究人员的合作，还积累了大量的生物学措施。 InChianti研究队列在1998-2000年、3年后、2001-2003年、6年后、2004-2006年、9年后、2007-2009年进行了基线评估，并于2013-2014年在两个研究中心完成了由托斯卡纳地区政府资助的第四波随访。在第四波中，进行了约687次访谈，并对参与者进行了560次临床检查。 随访检查重复基线评估的大部分内容。

InCHIANTI is being performed in two sites: Greve in Chianti (Site 1; 11,709 inhabitants; 19.3% > 65 years; located in the middle of a rural area) and Bagno a Ripoli (Village of Antella, site 2, 4704 inhabitants; 20.3% > 65 years; located immediately adjacent to the urban area of Florence). To obtain two representative samples of the population, the same two stage sampling procedure was used in each of the two sites. For the baseline cohort, in August 1998, a random sample of 1270 persons aged 65 years or older was randomly selected from the population registry of the two sites. Another 29 subjects were randomly selected among those who were 90 years old or older, until at least 30 men and 30 women from this age group were included in the sample. Finally, men and women randomly sampled from the age strata 20-29, 30-39, 40-49, 50-59, and 60-64 years were sequentially invited to participate in the study, until at least 30 men and 30 women for each decade from 20 to 59, and 15 men and 15 women aged 60 to 64 had been enrolled. An overarching hypothesis of the study is that most persons with walking disabilities have limitations in one or more of six physiologic subsystems and that the clinical evaluation of these subsystems can be valuable in planning both treatment and preventive interventions. These subsystems include: 1) Bones and joints; 2) Muscles; 3) Central nervous system; 4) Peripheral nervous system; 5) Perceptual system; and 6) Energy production and delivery. In addition to the clinical assessments done during the examination a large library of biological measures have been accumulated through NIA funding and collaborations with outside investigators. The InChianti Study cohorts were assessed at baseline in 1998-2000, 3 years later, in 2001-2003, 6 years later, in 2004-2006, 9 years later, in 2007-2009, and just completed a fourth wave of follow-up, funded by the Tuscany Region Government, in 2013-2014 at both sites. In the fourth wave, approximately 687 interviews were conducted and 560 clinical examinations of participants. Follow-up examinations repeat most elements of the baseline evaluation.