Mississippi site (Mississippi ECHO ISPCTN-2 (MS-CTN2)

项目总结 密西西比大学医学中心(UMMC)、密西西比儿童医院和密西西比大学医学中心 儿科正在寻求继续成为ECHO机构发展奖(IDEA)州的地点 儿科临床试验网络2(ISPCTN-2)。我们的网站密西西比ECHO ISPCTN-2(MS-CTN2)有 随着2016年实施第一个ISPCTN Fuding，取得了相当大的进展，大大扩大了我们的 机构基础设施和开放的2个儿科试验：肥胖儿童的维生素D补充- 儿童相关哮喘与未研究药物的药代动力学 CARE研究。 UMMC网站的总体目标是： 1.在以往网络成功的基础上，进一步增强我们的UMMC儿科临床研究团队，以 可靠地进行网络儿科临床试验； 2.在主要是农村和服务不足的社区促进参与儿科临床试验； 3.为美国国立卫生研究院的ECHO计划做出实质性贡献，以告知后代的健康 儿童；以及 4.扩大教职员工和机构能力建设基础设施，以便参与网络试验。 我们的ISPCTN网站通过增加儿科基础设施，为儿科试验做好了准备 在最初的筹资周期内提供支持。通过ISPCTN，我们网站的容量有了很大的增长 提供培训，与其他网站合作，并与密西西比中心进行机构合作 临床和转化研究(MCCTR)。我们的团队在试招方面积累了经验，将 在ISPCTN-2期间，继续在农村社区建设招募能力。UMMC的现场调查员 为ISPCTN计划做出了重要贡献，领导了工作组并制定了儿科 审判。通过在ISPCTN内建立的合作，学术工作产品得到了发展。 有了MS-CTN2，我们的网站将继续全面参与ECHO ISPCTN试验，包括那些寻求 改善对在宫内接触阿片类药物的婴儿的护理。通过ISPCTN-2，我们预计将开发、实施和 完成3项针对回声病优先事项的临床试验。此外，我们的初级教员将制定一项 通知IPSCTN-2多中心试验的研究方案。最后，我们的网站正在牵头一项提案，以测试 已经经过经验验证的心理社会干预，将这种干预扩展到高危婴儿和 横跨农村社区，代表着现有干预措施的新延伸。 我们的MS-CTN站点将成为农村和医疗领域的主要儿科研究中心 南方腹地服务不足的社区。在一如既往的支持下，我们的网站将从 扩大到农村社区的试验，从而增加了儿科试验研究的普适性。

PROJECT SUMMARY The University of Mississippi Medical Center (UMMC), Children’s of Mississippi, and the UMMC Department of Pediatrics are seeking to continue to be a site for the ECHO Institutional Development Award (IDeA) States Pediatric Clinical Trials Network-2 (ISPCTN-2). Our site, the Mississippi ECHO ISPCTN-2 (MS-CTN2) has made considerable progress with implementation of the initial ISPCTN fuding in 2016, greatly expanding our institutional infrastructure and opening 2 pediatric trials: Vitamin D Supplementation in Children with Obesity- Related Asthma and the Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care study. The UMMC site’s overarching objectives are: 1. Build upon previous Network success and further enhance of our UMMC pediatric clinical research team to reliably conduct Network pediatric clinical trials; 2. Promote engagement in pediatric clinical trials across largely rural and underserved communities; 3. Make substantive contributions to the NIH’s ECHO program that inform the health of future generations of children; and 4. Broaden faculty, staff, and institutional capacity-building infrastructure for engagement in Network trials. Our ISPCTN site has increased readiness for pediatric trials through increasing pediatric infrastructure supports during the initial funding cycle. The capacity of our site has grown considerably through ISPCTN provided trainings, collaborations with other sites, and institutional collaboration with the Mississippi Center for Clinical and Translational Research (MCCTR). Our team has gained experience in trial recruitment and will continue to build capacity for recruitment in rural communities during ISPCTN-2. Site investigators at UMMC have made important contributions to the ISPCTN program, leading working groups and developing a pediatric trial. Scholarly work products have grown through collaborations established within the ISPCTN. With MS-CTN2, our site will continue to be fully engaged with ECHO ISPCTN trials, including those that seek to improve care for infants exposed to opioids in utero. With ISPCTN-2 we expect to develop, implement and complete 3 clinical trials that address ECHO disease priorities. In addition, our junior faculty will develop a research protocol that informs an IPSCTN-2 multi-center trial. Finally, our site is leading a proposal to test an already empirically validated psychosocial intervention, extending this intervention to high risk infants and across rural communities, representing a novel extension to an existing intervention. Our MS-CTN2 site is poised to become a major pediatric research center in the rural and medically underserved communities of the deep South. With continued support our site will contribute new data from trials that extend into rural communities, thus increasing the generalizability from pediatric trials research.