Mississippi site (Mississippi ECHO ISPCTN-2 (MS-CTN2)

项目摘要/摘要 这项拟议的多样性研究补充材料旨在扩大 密西西比州环境对儿童健康结局的影响(ECHO)IDEA州儿科 临床试验网络(ISPCTN)通过确定障碍和促进者获得第2周期家长奖 儿科临床试验，增加我们对新冠肺炎大流行影响的了解 关于密西西比州的家庭，并支持一个有前途的多样化的早期职业调查员，Tre 他将为儿科临床试验和NIH的多样性做出贡献 劳动力。学员近期的职业发展目标是：1)增加知识 参加ECHO ISPCTN赞助的培训，参与儿科临床试验研究 和会议、当地现场活动、工作组、指导和职业发展 活动，2)通过出版多个第一作者来扩大手稿和授予写作技能 手稿和在国家会议上传播研究计划的结论，以及3) 通过参加高级培训来提高儿童临床心理学技能，这些培训将使 ECHO ISPCTN临床试验概念提案和K奖拨款的开发 呈件。为了实现这些培训目标，这项为期两年的研究计划将审查来自 一项全州范围的电话调查，包括600名照顾者，并专注于这项研究 以下目标：1)检查儿科临床试验的障碍和促进者 为患有Echo相关慢性疾病的青少年提供照顾者，以制定有针对性的策略 以改进我们现场和更大的ECHO ISPCTN中的试验设计，以及2)比较 新冠肺炎大流行对农村和城市社区家庭心理健康功能的影响。 拟议的多样性研究补充和培训计划延长了家长奖的 通过产生新知识来产生科学影响，这些知识将为当前和未来的儿科 临床试验设计与我们当地和地区的登记、参与、保留和完成有关 其他ECHO ISPCTN网站。历来，儿童在临床试验中的代表性不足。 研究人员和来自农村和服务不足社区的人面临着额外的差距 与获得临床试验和研究有关。为了继续改善所有人的健康 对于儿童，需要使儿科临床试验和NIH工作人员多样化，以及 更好地了解参与儿科临床的家庭的障碍和促进者 试验研究，这是本多样性研究补充的重点。

Project Summary/Abstract This proposed Diversity Research Supplement aims to extend the scientific impact of the Mississippi Environmental Influences on Child Health Outcomes (ECHO) IDeA States Pediatric Clinical Trials Network (ISPCTN) Cycle 2 parent award by identifying barriers and facilitators to pediatric clinical trials, increasing our understanding of the impact of the COVID-19 pandemic on families in Mississippi, and support a promising diverse early career investigator, Tre Gissandaner, MA, who will contribute to the diversity of the pediatric clinical trials and NIH workforces. The mentee’s immediate career development goals are to: 1) increase knowledge related to pediatric clinical trials research by engaging in ECHO ISPCTN sponsored trainings and meetings, local site activities, working groups, mentoring, and professional development activities, 2) expand manuscript and grant writing skills by publishing multiple first author manuscripts and disseminating findings from the research plan at national conferences, and 3) enhance child clinical psychology skills by participating in advanced trainings that will inform the development of an ECHO ISPCTN clinical trials concept proposal and K award grant submission. To achieve these training goals, the two-year research plan will examine data from a state wide telephone survey, which included 600 caregivers and focus on the research following aims: 1) examine barriers and facilitators to pediatric clinical trials identified by caregivers of youth with ECHO related chronic medical conditions to develop targeted strategies to improve trial designs at our site and in the larger ECHO ISPCTN, and 2) compare impact of COVID-19 pandemic on mental health functioning in families from rural and urban communities. The proposed diversity research supplement and training plan extends the parent award’s scientific impact by generating new knowledge that will inform current and future pediatric clinical trial design related to enrollment, participation, retention, and completion at our local and other ECHO ISPCTN sites. Children have historically been under-represented in clinical trials research and those from rural and underserved communities experience additional disparities related to access to clinical trials research. In order to continue to improve the health of all children, there is a need to diversify the pediatric clinical trial and NIH workforce, as well as better understand barriers and facilitators regarding families participating in pediatric clinical trials research, which are the focus of this diversity research supplement.