Omics Core

OMICS核心的主要功能是为路易斯维尔大学的成员提供酒精研究 中心(ULARC)，拥有代谢组、蛋白质组和 收集的生物样本的生物信息学分析，以研究营养、肠道菌群/肠道功能障碍和 酒精引起的器官损伤和治疗干预。组学核心人员将协助设计 样本采集协议，将推动新的和健壮的开发和执行 样品分离的色谱法和蛋白质分析的质谱法， 多肽和代谢物，目的是更好地了解分子的进化 与肝功能障碍相关或参与肝功能障碍的机制。组学核心将确保统一性和 样品制备、方法开发、仪器性能、数据收集、数据的标准化 报告和数据共享。组学核心致力于为 并加强该机构的基础设施以及技术和学术能力 完整的。组学核心还将促进ULARC成员在以下方面的教育和培训 最先进的组学技术。此外，OMICS Core将成为一个独立的、自我的 支持实体使用一套已经实施并已实施的综合方法 展示了他们在我们目前的ULARC中的成功。OMICS核心预计将提供必要的和 对所有ULARC项目的基本支持。

The primary function of OMICS Core is to provide members of the University of Louisville Alcohol Research Center (ULARC) with the expertise, resources, and facilities needed for metabolomic, proteomic, and bioinformatic analyses of biological samples collected to study nutrition, gut flora/intestinal dysfunction and alcohol-induced organ injury, and therapeutic interventions. OMICS Core personnel will assist with the design of sample collection protocols, will drive the development and the execution of novel and robust chromatographic methods for sample separation and mass spectrometric methods for the analysis of proteins, peptides and metabolites with a goal of providing a greater understanding of the evolution of molecular mechanisms that correlate with or participate in liver dysfunction. OMICS Core will ensure uniformity and standardization in sample preparation, method development, instrument performance, data collection, data reporting, and data sharing. OMICS Core endeavors to contribute to the overall success and utility of the ULARC and to enhance the infrastructure and the technical and academic capabilities of the institution as a whole. OMICS Core will also promote the education and training of the ULARC members with regards to the state-of-the-art omics technologies. Furthermore, OMICS Core will become an independent and self- supporting entity using a set comprehensive approaches that have been already been implemented and have demonstrated their success in our current ULARC. The OMICS Core is projected to provide necessary and essential support to all ULARC projects.