Endoscopic Multifunctional Optical Coherence Tomography for Airway Tissue Injury Management

项目总结/摘要 吸入性损伤是平民发病和死亡的一个重要原因。它通常是由 吸入烟雾或有毒气体，如一氧化碳、氰化氢、二氧化氮等。 支气管镜检查目前被用作吸入性损伤评估的标准方法。然而，它未能 提供粘膜下和功能组织信息，这两者对于正确的分诊和选择至关重要 适当的治疗。物理科学公司，与位于查佩尔山的北卡罗来纳州大学合作， 提出研制一种新型的内窥镜多功能气道光学相干断层扫描仪 组织损伤管理，将为临床医生提供有关形态和 损伤组织的功能变化。该仪器将补充定性支气管镜检查结果， 定量的粘膜下形态和功能信息，如纤毛活动和顺应性， 将能够更有效地筛查、分类和指导吸入暴露的治疗。 第一阶段计划的目标是证明所提出的技术的可行性， 吸入性损伤评估，而在第二阶段，将建议开发一种先进的临床仪器 并在急性吸入性损伤的人类患者上进行了初步测试。

Project Summary/Abstract Inhalation injury is an important cause of morbidity and mortality in the civilian population. It is usually caused by the inhalation of smoke or toxic gases, such as carbon monoxide, hydrogen cyanide, nitrogen dioxide, etc. Bronchoscopy is currently used as a standard approach for inhalation injury assessment. However, it fails to provide submucosal and functional tissue information, both of which are essential for proper triage and selection of appropriate therapy. Physical Sciences Inc., in collaboration with the University of North Carolina, Chapel Hill, proposes to develop a novel Endoscopic Multifunctional Optical Coherence Tomography instrument for Airway Tissue Injury Management that will provide clinicians with real-time feedback regarding the morphological and functional changes of the injured tissue. This instrument will complement qualitative bronchoscopic findings with quantitative submucosal morphological and functional information, such as ciliary activity and compliance, which will enable more efficient screening, triage, and therapeutic guidance of inhalation exposures. The goal of the Phase I program is to demonstrate the feasibility of the proposed technology for airway inhalation injury assessment, while in Phase II an advanced clinical instrument will be proposed to be developed and preliminarily tested on human patients of acute inhalation injury.