BIOSTATISTICS AND DATA BASE CORE

该核心项目的总体目标是为联合国系统内的四个项目提供生物统计和数据库支持。 计划项目和核心B：行为评估核心的研究者和工作人员，并促进 传播的基因型和表型数据所产生的动物模型的睡眠在年轻和 更大的科学界（数据共享）。为了实现这一目标，核心将 如下： I.与研究者合作开发稳健的研究设计，澄清假设，确定样本量， 实验要执行，并促进统计思维和有效的应用， 科学方法贯穿整个过程。 与研究者合作，分析正在进行的研究中获得的数据，并协助 编写文稿，包括说明所采用的统计方法。 确保整个研究计划中采用的统计方法是最先进的 and to introduce介绍new新strategies策略to address地址the scientific科学needs需求of the program程序. 4.为核心B提供非侵入性行为筛查以及离群值的最佳方法 i）从C5排除数据？BL/6 NIA小鼠表现出非正常 睡眠/觉醒行为和2）从分析中排除表现出非正常性C57 BL/6 NIA小鼠 改变EEG/EMG植入手术后的睡眠/觉醒行为，以减少剩余方差， 进行组和实验条件比较，涉及特定项目的主要和 支持成果措施。 提供并维护多服务器存储、数据库和Web基础架构及软件 支持研究操作、数据管理和数据共享的应用程序。该系统和 附带的软件应用程序将强调元数据，并将采用最佳数据 管理实践和数据模型来自工业和研究界。该系统将 具有用于（i）存储和共享基因型和表型的综合数据库结构 果蝇寿命期内睡眠/觉醒行为的信息，以及EEG/EMG、视频和 年轻、中年和老年小鼠的其他睡眠/觉醒行为数据;（2）直接制作数据 研究人员可以访问，以确保数据、数据文件和研究的整合， 业务和活动。这些数据将通过一个网络系统向所有人提供 节目中的调查员。将对选定的数据进行认真的定性，并提供给 通过开发一个新网站扩大科学界SomnoGen这将作为 一个资源表型和基因型信息有关睡眠在年轻和老年动物。

The overall goal of this Core is to provide biostatistical and data base support to the four projects in the Program Project and to the investigators and staff of Core B: BehavioralAssessment Core and to facilitate dissemination ofgenotypic and phenotypic data arising from animal models of sleep in both young and older animals to the larger scientific community (data sharing). To accomplish this goal, the Core will do the following: i. Work with investigators to develop robust study designs, clarify hypotheses, determine sample sizes for experiments to be performed, and to promote statistical thinking and the valid application of the scientific method throughout the Program. Work with investigators to analyze data obtained in the studies being conducted and to assist in preparation of manuscripts, including description of the statistical approaches employed. Ensure that the statistical approaches employed in the overall program of research are state-of-the art and to introduce new strategies to address the scientificneeds ofthe program. 4. Provide to Core B optimal methodologyfor non-invasive behavioral screening coupled with outlier detection to facilitate i) exclusion of data from C5?BL/6NIA mice that exhibit non-normative sleep/wake behavior and 2) exclusion from analyses C57BL/6NIA mice that exhibit non-normative changes sleep/wake behavior after EEG/EMG implantation surgery to reduce residual variance when performing group and experimental condition comparisons involving project-specific primary and supporting outcome measures. Provide and maintain a multi-server storage, database, and web infrastructure and software applications to support research operation, data management, and data sharing. The system and accompanying software applications will have an emphasis on metadata and will adopt best data management practices ana data modelsfrom the industry and research community. This system will have a comprehensive database structure for (i) storing and sharing genotypic and phenotypic information for sleep/wake behavior across the lifespan in Drosophila and EEG/EMG, video, and other sleep/wake behavioral data in young, middle age,and old mice; (2) making the data directly accessible to researchers to ensure an integration of data, documentation of data, and research, operations and activities. These data will be made available by a web-enabled system to all investigators in the program. Selected data will be carefully characterized and made available to the larger scientific communitythrough the developmentofa new web-siteSomnoGenthat willserve as a resourcefor phenotypic and genotypic information concerning sleep in young and older animals.