REGIONAL BRAIN CONTROL OF LABORATORY INDUCED AGGRESSION AS ASSESSED BY FDG PET

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 冲动性攻击是人格障碍患者的一个重要临床问题，但它是一种间歇性行为，很难研究。因此，有必要对人格障碍中的冲动性攻击性进行实验室评估。在这项研究中，我们建议使用实验室的攻击测量，点减法攻击范式(PSAP)来研究18FDG-PET在患有冲动性攻击的人格障碍受试者和对照对照组之间的脑激活模式的差异。在完成PSAP后，我们建议想象3名冲动性人格障碍受试者和3名非冲动性对照受试者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Impulsive aggression is an important clinical problem in patients with personality disorders; however, it is a difficult behavior to study in that it is an intermittent behavior. It is, therefore, essential to develop a laboratory assessment of impulsive aggression in personality disorders. In this study we propose to use a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (PSAP) to study differences in brain activation patterns using 18FDG- PET between personality disordered subjects with impulsive aggression and comparison controls. We propose to image 3 impulsive personality disorder subjects, and 3 non-impulsive comparison subjects after completion of the PSAP.