Environmental Influences on Child Health Outcomes in the Northern Plains Safe Passage Study Cohort

项目摘要/摘要 这项提案的首要前提是现有和拟议的队列(n&gt；4400)、基础设施、 和PASS-ECHO的调查团队独一无二地准备回答与 产前和儿童早期环境暴露对以后的健康结果的影响。为了实现这一目标， 这项研究将建立在小岛屿发展中国家通过产前酒精建立的成功研究基础之上 和静止出生(PASS)网络(NICHD U02-HD045935)，并将利用这一独特的队列提供丰富的 产前和婴儿数据可以扩大ECHO研究在神经发育领域的能力， 神经生理学和哮喘，特别是在农村和美国印第安人青年中。传递回声 调查团队在进行复杂和高质量的研究方面有良好的记录，同时保持 该地区的纵向参与者和社区参与。作为共同议定书的补充， PASS-ECHO队列将检查与个人、家庭和社会层面因素并行的深入数据。 这项建议关注神经发育和哮喘结果，PASS-ECHO队列能够 包括为其他回声焦点区域提供额外数据的额外措施。传递回声 调查人员、基础设施和队列有能力为满足总体需求做出重大贡献 回声的目标。

Project Summary/Abstract The overarching premise of this proposal is that the extant and proposed cohorts (n>4400), infrastructure, and investigative team of PASS-ECHO are uniquely poised to answer questions relating to the impact of prenatal and early childhood environmental exposures on later health outcomes. To accomplish this objective, the study will build upon the successful study infrastructure established through the Prenatal Alcohol in SIDS and Stillbirth (PASS) Network (NICHD U02-HD045935) and will utilize this unique cohort to provide a wealth of prenatal and infant data that can expand the capability of the ECHO study in areas of neurodevelopment, neurophysiology, and asthma, particularly among rural and American Indian youth. The PASS-ECHO investigative team has a proven track record in conducting complex and high quality studies while maintaining longitudinal participant and community engagement in the region. Complementary to the common protocol, the PASS-ECHO cohort will examine in-depth data concurrent to individual-, family-, and social-level factors .While this proposal focuses on neurodevelopmental and asthma outcomes, the PASS-ECHO cohort is capable of including additional measures to provide additional data for the other ECHO focus areas. The PASS-ECHO investigators, infrastructure, and cohort have the capacity to contribute significantly to meet the overarching goal of ECHO.