The Colorado Building Interdisciplinary Research Careers in Women's Health Program

项目摘要 此申请是为科罗拉多建筑跨学科研究职业生涯提供第三个周期的资金 妇女健康研究(BIRCWH)K12计划，成立于2007年。在过去的近10年里，我们 已有14名学者参加了该计划，其中12人仍在学术医学领域，11人已获得 外部资助(3个尚未获得资助的人中有2个是较新的学者)，他们总共产生了 90篇出版物(不包括摘要)。对于我们提议的第三个周期，借鉴我们在前两个周期中的经验 在BIRCWH的周期中，我们提出了几个关键的计划创新：1)增加了经过验证的研究和职业 将课程开发到计划(替换旧课程)，同时确保不会中断 学者研究时间。2)增加精准医疗作为重点领域，提供前沿、交叉 切入主题，将我们的焦点交织在一起。3)学者们将写下他们的第一个个人K奖 在时间上(在BIRCWH学者任命的第8-9个月)比前几年早。在我们的试运行测试中 这种方法，在不改变遴选过程的情况下，目前的BIRCWH学者正在获得 个人外部资助，成功率不断提高。4)在完成后继续使用SAC BIRCWH奖学金期间(如果个人K是下一步或通过写R)来提供持续 指导通过职业发展阶段，同时建立独立性。这已经被证明是非常 成功地帮助学者进步。5)与医学博士Shanta Zimmer合作，新任副院长 多样性，以增加使用新的UC-SOM计划的BIRCWH学者的多样性，并增加 生物统计学的可用性，以满足学者们复杂的统计需求。我们的具体目标是： 支持来自全国范围内极具动力和才华的3名顶尖申请者，并提供 为他们提供适当定制、高质量的跨学科指导研究体验；提供 拥有来自内科和妇产科内外杰出导师的学者，包括 心脏病学、内分泌学、流行病学、免疫学、综合生理学、分子生物学、 儿科学、精准医学和精神病学等，他们都是资深科学家，具有强大的 资金和培训的跟踪记录，并培养准备解决关键问题的跨学科团队科学家 研究女性健康和性别差异方面的问题。我们的内部计划咨询委员会将 继续评估计划的运作和进展；我们的外部计划咨询委员会将 提供一个外人对BIRCWH的概述，以确保我们与全国女性服装趋势保持同步 健康与性别差异研究。对科罗拉多州BIRCWH的出色机构支持，包括 妇女健康研究中心和其他支持BIRCWH的团体也将推动这一增长 旨在发展成功的、独立的跨学科科学家职业生涯的重要计划 研究女性的健康和性别差异，从而提高女性的健康水平。

Project Summary This application is for the 3rd cycle of funding for the Colorado Building Interdisciplinary Research Careers in Women’s Health Research (BIRCWH) K12 program, established in 2007. Over the past almost 10 years, we have had 14 Scholars in the program, 12 of whom have remained in academic medicine, 11 have received external funding (2 of the 3 not yet funded are more recent Scholars) and who collectively have produced over 90 publications (not including abstracts). For our proposed third cycle, learning from our experience in two prior cycles of BIRCWH, we propose several key program innovations: 1) Adding a proven research and career development curriculum to the program (replacing old curriculum) while ensuring that there is no disruption of Scholar research time. 2) Adding Precision Medicine as a focus area, thus providing a cutting edge, cross- cutting theme that will serve to interweave our foci together. 3) Scholars will write their first individual K award earlier in time (in the 8th-9th month of a BIRCWH Scholar’s appointment) than in prior years. In our pilot test of this approach, without any change in the selection process, current BIRCWH Scholars are obtaining individual external funding with increasing rates of success. 4) Continued use of SAC following completion of BIRCWH Scholar period (if an individual K is the next step or through writing the R) to provide ongoing guidance through the career development period while establishing independence. This has proven to be very successful in helping Scholars progress. 5) Working with Shanta Zimmer, MD, new Associate Dean for Diversity, to increase diversity of BIRCWH Scholars using the new UC-SOM plan and 6) Increased biostatistian availability to meet the complex statistical needs of the Scholars. Our specific aims are to: Support 3 top applicants from a national pool of exceptionally motivated and talented individuals, and provide them with an appropriately tailored, top-quality interdisciplinary mentored research experience; Provide Scholars with outstanding mentors from within and without the departments of Medicine and Ob/Gyn, including expertise in Cardiology, Endocrinology, Epidemiology, Immunology, Integrative Physiology, Molecular Biology, Pediatrics, Precision Medicine and Psychiatry, among others, all of whom are senior scientists with strong track records of funding and training, and nurture interdisciplinary team scientists poised to address key research problems in women’s health and sex differences. Our Internal Program Advisory Committee will continue to evaluate program operations and progress; our External Program Advisory Committee which will provide an outsider’s overview of the BIRCWH to assure that we stay abreast of national trends in women’s health and sex difference research. The excellent institutional support for the Colorado BIRCWH, including the Center for Women’s Health Research and other groups that support BIRCWH, will also fuel the growth of this important program which aims to develop successful, independent interdisciplinary careers of scientists in women’s health and sex differences research and thereby improve the health of women.