Administrative Core

摘要：行政核心 在接下来的5年里，南加州大学ADRC建议继续关注血管对认知功能的贡献， 损伤和阿尔茨海默病（AD），血管和代谢危险因素（VMRF），神经血管单位 (NVU)以及与AD生物标志物（β-淀粉样蛋白和p-Tau）、脑结构和功能以及认知的关系 （总体目标1）;为美国红十字会附属研究和南加州大学赞助者发起的研究提供基础设施 临床试验（总体目标2）;并为国家血管疾病，生物标志物和成像提供专业知识 （总体目标3）。行政核心将提供领导、行政机制和 监督，使我们的ADRC能够实现其整体目标。通过提供明确和透明的机制， 沟通、资源分配、预算管理和确保所有监管和患者安全 在遵守这些程序的情况下，行政核心将进一步完成 本提案的其他内容。在下一个资助周期中，ADRC将积极跟踪650名参与者（25% 拉丁裔），目的是富集高VMRF（66%）和脑血管表型可用性， 神经成像和生物流体生物标记（例如，DCE-MRI、OCTA、TCD、血管分子生物标志物）。自抗扰控制 将继续提供基础设施和专业知识，为美国药物研究中心附属的研究，南加州大学的研究员- 启动临床试验以及多中心临床研究和试验。我们的发展项目将继续 从事和招募南加州大学教师和他们的学员到南加州大学的AD研究。ADRC将继续做出贡献 血管疾病、生物标志物和神经影像学方面的专业知识直接提供给国家合作倡议1） 通过参与国家阿尔茨海默病协调中心（NACC），国家集中知识库， AD（NCRAD），阿尔茨海默病遗传学联盟（ADGC），阿尔茨海默病神经影像学倡议 （ADNI）和阿尔茨海默氏症临床试验联盟（ACTC）;以及2）通过几个ADRC附属的国家和 国际独立资助的研究，如LONI，ADNI，人类连接组项目，GAAIN，ENIGMA 目前正在验证我们的新成像技术的多机构国家和国际项目， 生物流体血管生物标志物。

Abstract: Administrative Core During the next 5 years, the USC ADRC proposes to continue its focus on vascular contributions to cognitive impairment and Alzheimer’s disease (AD), vascular and metabolic risk factors (VMRF), the neurovascular unit (NVU), and relationship with AD biomarkers (β-amyloid and p-Tau), brain structure and function and cognition (Overall aim 1); to provide infrastructure for ADRC-affiliated research studies and USC investigator-initiated clinical trials (Overall aim 2); and contribute expertise in vascular disease, biomarkers, and imaging to national initiatives (Overall aim 3). The Administrative Core will provide the leadership, administrative mechanisms and oversight to enable our ADRC to achieve its overall aims. By providing a clear and transparent mechanism for communication, resource allocation, budget management and insuring all regulatory and patient safety processes are adhered to, the Administrative Core will further the overall missions as described in each of the other components of this proposal. In the next funding cycle the ADRC will actively follow 650 participants (25% Latino), with the intention of enriching for high VMRF (66%) and availability of cerebrovascular phenotyping using neuroimaging and biofluid biomarkers (e.g., DCE-MRI, OCTA, TCD, vascular molecular biomarkers). The ADRC will continue to provide infrastructure and expertise for ADRC-affiliated research studies, USC investigator- initiated clinical trials, and multi-center clinical studies and trials. Our development projects will continue to engage and recruit USC faculty and their trainees into AD research at USC. The ADRC will continue contributing expertise in vascular disease, biomarkers and neuroimaging to collaborative national initiatives directly 1) through participation in the National Alzheimer Coordinating Center (NACC), National Centralized Repository for AD (NCRAD), Alzheimer Disease Genetics Consortium (ADGC), Alzheimer Disease Neuroimaging Initiative (ADNI), and the Alzheimer Clinical Trials Consortium (ACTC); and 2) via several ADRC-affiliated national and international independently-funded studies such as LONI, ADNI, Human Connectome project, GAAIN, ENIGMA Consortium, and multi-institutional national and international programs currently validating our new imaging and biofluid vascular biomarkers.