Development and Validation of a Collaborative Web/Cloud-Based Dosimetry System for Radiopharmaceutical Therapy.

项目摘要 放射性药物治疗（RPT）-使用靶向放射性核素将辐射特异性地输送到 癌细胞及其微环境-是一种正在发展的从根本上不同的癌症治疗方法， 大量的大型和小型制药公司在这一领域开发产品， 放射性核素生产商为扩大生产规模进行了大量投资。更是如此 阿尔法发射器治疗性放射性药物的剂量学评价是 RPT的监管批准和最佳给药，特别是与外部射束辐射联合使用 疗法该项目将提供基于云的剂量测定软件服务，通过网络浏览器提供， 这包括在获得监管批准的背景下进行剂量测定所需的全部补充方法 并最终实现最佳临床交付。在基于云的系统中提供这一点将使各种 不需要对诊所进行大量前期资本投资的服务销售模式， 放射性药物开发商。它还将提供专家咨询，定制和剂量测定 服务，并允许开发人员，剂量测定专家和临床站点之间的协作。完成 为了开发这种基于云的Web浏览器交付的RPT剂量测定软件服务，我们提出了 以下具体目标：（1）设计，开发和实施基于Web/云的集成软件系统， RPT治疗的治疗计划;（2）设计并实现用于订阅的完整服务器端框架， 认证，并为剂量测定管道中的各种过程和数据授予协作权限; (3)优化和调整四个计算最密集的过程，以实现基于多处理器云的 计算环境;（4）应用和评估在目标1-3中开发的工具链， 现有患者数据。该项目的成功完成将产生一个基于云的软件系统交付 通过Web浏览器提供给用户，该浏览器为RPT提供了集成的、精简的、强大的、最先进的系统 治疗计划该系统将使多中心临床试验的协作方法成为可能， 最终用于临床输送最佳剂量的RPT。

Project Summary Radiopharmaceutical therapy (RPT) – the use of targeted radionuclides to deliver radiation specifically to cancer cells and their microenvironment – is a fundamentally different approach to cancer therapy that is growing, with a substantial number of large and small pharmaceuticals companies developing products in this area and radionuclide producers making substantial investments in scaling up production. This is especially true in the area of alpha emitters. The dosimetric evaluation of therapeutic radiopharmaceuticals is a key requirement for regulatory approval and optimal administration of RPTs, especially in combination with external beam radiation therapy. This project will provide a cloud-based dosimetry software service, delivered through a web-browser, that includes the full complement of methods needed for dosimetry in the context of obtaining regulatory approval of RPTs and, ultimately, for optimal clinical delivery. Providing this in a cloud-based system will enable a variety of models for selling the service that do not require a large up-front capital investment for clinics or radiopharmaceutical developers. It also will provide access to expert advice, customization, and dosimetry services, and allow for collaboration between developers, dosimetry experts, and clinical sites. To accomplish the goal of developing this cloud-based web-browser-delivered RPT dosimetry software service, we propose the following specific aims: (1) Design, develop and implement a web/cloud-based integrated software system for treatment planning of RPT therapy; (2) design and implement a full server-side framework for subscription, authentication, and granting collaborative privileges for the various processes and data in the dosimetry pipeline; (3) optimize and adapt the four most computationally intensive processes for a multi-processor cloud-based compute environment; (4) apply and evaluate the toolchain developed in aims 1-3 to phantom, simulated and existing patient data. Successful completion of this project will produce a cloud-based software system delivered to the user via a web browser that provides an integrated, streamlined, robust, state-of-the-art system for RPT treatment planning. This system would enable a collaborative approach to multi-center clinical trials and eventually to clinical delivery of optimally dosed RPT.