Modulation effects of imagined acupuncture and no touch placebo acupuncture

总结 这个合作/培训补充申请的目标是：1）访问高仓健博士在东京有明的实验室 医学与健康科学大学学习如何使用双盲安慰剂针灸针 由他的团队发明; 2）启动一个合作项目，调查/比较底层大脑 机制（使用脑电图），镇痛效果和针刺感觉（得气感觉） 在亲本R61/R33中开发的针灸成像治疗（VGAIT）和双盲无接触 安慰剂针灸针由高仓健博士和同事开发。 与家长资助的相关性、BRCP的目标和参与NIH研究所的使命， 正在进行的亲本R61/R33旨在比较研究VGAIT的调节作用， VGAIT控制条件，真实的针灸，和假针灸在健康受试者和患者 膝骨关节炎（OA）。在父母补助金中，不包括VGAIT期间和之后的EEG数据收集。 此外，我们选择了Streitberger安慰剂针，这是一种单盲安慰剂针，钝头， 接触皮肤，提供表面温和刺激，并与皮肤表面进行物理接触。这 补充项目将探讨VGAIT期间和之后的大脑活动（通过EEG测量）， 触摸，双盲安慰剂针。研究结果将进一步加深我们对 VGAIT和假针刺的潜在机制。 该补充材料将支持PI及其团队成员访问日本，并在那里接受培训 如何使用双盲针灸针，并与高仓健博士进行合作研究， 东京有明医科大学针灸系主任， 健康科学。高仓健博士在针灸研究和临床实践方面都有丰富的经验。 这一申请是对BRCP宗旨的直接回应，旨在促进科学家交流， 培训，以及来自美国的神经科学家之间的基础，转化和临床研究合作。 以及NCCIH加强替代医学研究的目标，包括 想象安慰剂和针灸

Summary The goal of this collaborating/training supplement application is to 1) visit Dr. Takakura’s lab at Tokyo Ariake University of Medical and Health Sciences to learn how to use the double-blinded placebo acupuncture needle invented by his team; and 2) launch a collaborative project to investigate/compare the underlying brain mechanism (using EEG), analgesic effects and acupuncture sensations (deqi sensation) of video-guided acupuncture imagery treatment (VGAIT) developed in parent R61/R33 and of the double blinded no touch placebo acupuncture needle developed by Dr. Takakura and colleagues. Relevance to parent grant, goals of the BRCP and the mission of the participating NIH Institutes and Centers The ongoing parent R61/R33 aims to comparatively investigate the modulation effects of VGAIT, a VGAIT control condition, real acupuncture, and sham acupuncture in both healthy subjects and patients with knee osteoarthritis (OA). In the parent grant, EEG data collection during and after VGAIT is NOT included. Also, we have chosen the Streitberger placebo needle, a single-blinded placebo needle with a blunt tip that can touch the skin, provide superficial mild stimulation and make physical contact with the surface of the skin. This supplemental project will explore the brain activity (as measured by EEG) during and after VGAIT and no touch, double-blinded placebo needles. Results obtained will further enhance our understanding of the underlying mechanism of VGAIT and sham acupuncture. This supplement will support the PI and his team member in their visit to Japan, where they will receive training on how to use the double-blinded acupuncture needle and conduct collaborative research with Dr. Takakura, the president of the Department of Acupuncture and Moxibustion at Tokyo Ariake University of Medical and Health Sciences. Dr. Takakura has extensive experience in both acupuncture research and clinical practice. This application is a direct response to the purpose of the BRCP, aiming to promote scientist exchange, training, and collaborations in basic, translational, and clinical research between neuroscientists from the U.S. and Japan, as well as the goal of the NCCIH to enhance the research of alternative medicine, including imagery, placebo, and acupuncture.