Administrative Core

波士顿人类肿瘤图谱网络研究中心(HTA-RC)的首要目标是 为了创建人类黑色素瘤细胞地理的三个综合图集， 结直肠癌和乳腺癌，以了解肿瘤生态系统的变化 导致每个人都产生治疗抵抗。这些地图集将绘制出数字、自然、 以及区分耐药肿瘤的细胞和组织结构的空间关系 到靶向和免疫治疗。行政核心将负责 波士顿HTA-RC的领导、治理和责任。核心将协调和 评估研究中心(RC)的每个组成部分；提供所有组件的运营监督 计划的各个方面；并监测实现里程碑的进展情况。特别是，核心将 全面管理和协调驻地协调员的活动(目标1)。它将监控 朝着里程碑目标取得进展，监督财务支出，并为所有人提供支持 中心活动的方方面面，通过：与中心领导层和单位密切联系 领导；项目管理和财政监督；以及来自当地指导的持续指导 由相关领域的领域专家组成的委员会。核心还将提供后勤 支持和促进区域中心内外的沟通(目标2)，以确保动态 中心所有元素之间的相互作用。项目经理将监督信息流， 物理样品和单元之间的技术，利用最先进的电子 跟踪系统、实时和透明的帮助以及通过定期领导进行的积极互动 会议、指导委员会会议、外部顾问委员会和年度务虚会。这个 波士顿HTA-RC将深深扎根于充满活力的临床和科学社区 DFCI、布罗德和马萨诸塞州综合医院(MGH)、哈佛大学、斯坦福大学和核心医院 还将负责与更广泛的HTA网络数据协调 中心和国家情报局。最后，核心将评估实现里程碑的进展情况(目标3)， 关于我们开发的一系列量化里程碑。它将定期评估里程碑式的进展 在此基础上，向领导团队提供报告，并针对任何阻碍问题或 与NCI计划官员讨论所需的里程碑式修订。

The overarching goal of the Boston Human Tumor Atlas Network Research Center (HTA-RC) is to create three comprehensive atlases of the cellular geography of human melanoma, colorectal cancer, and breast cancer, to understand how changes in the tumor ecosystem lead each to therapeutic resistance. The atlases will map the topography of the number, nature, and spatial relationship of cells and histological structures that distinguish those tumors resistant to targeted and immune-based therapies. The Administrative Core will be responsible for the leadership, governance, and accountability of the Boston HTA-RC. The Core will coordinate and evaluate each component of the Research Center (RC); provide operational oversight of all aspects of the program; and monitor progress toward milestones. In particular, the Core will Provide overall management and coordination of RC activities (Aim 1). It will monitor progress toward the milestone goals, oversee financial expenditures, and provide support for all facets of the Center's activities, through: liaising closely with the Center's leadership and unit leads; project management and fiscal oversight; and on-going guidance from a local steering committee comprising domain experts in relevant fields. The core will also provide logistical support and facilitate communication within and outside the RC (Aim 2), to ensure dynamic interaction between all elements of the Center. A project manager will oversee flow of information, physical samples, and technologies between Units, leveraging both state-of-the-art electronic tracking systems, live and transparent aids, and active interaction through regular leadership meetings, steering committee meetings, an external advisory board, and an annual retreat. The Boston HTA-RC will be deeply embedded in the vibrant clinical and scientific communities at DFCI, Broad, and Massachusetts General Hospital (MGH), Harvard, and Stanford, and the Core will also be responsible for communication with the broader HTA network, the Data Coordinating Center, and the NCI. Finally, the core will evaluate progress toward milestones (Aim 3), based on a series of quantitative milestones we developed. It will assess milestone progress on a regular basis, provide reports to the Leadership Team, and develop proposals for any blocking issues or milestone revisions needed for discussions with NCI Program Officials.