Center for Cell-based Therapy - Cures

细胞治疗中心的使命是促进癌症患者细胞免疫疗法的发现和开发。这项工作的两个重要目标是：（1）开发利用基于细胞的免疫疗法成功靶向实体瘤的方法，以及（2）促进具有强大临床潜力的基于细胞的合作治疗项目。该项目目前正在开发的四个领域是：（1）与Mitchel Ho，Rosandra Kaplan和Carol Thiele合作开发靶向GPC 2的CAR-T细胞作为神经母细胞瘤的治疗方法;（2）与Mitchel Ho和伊拉帕斯坦合作创建靶向间皮素的CAR-T细胞作为间皮瘤和肺腺癌的治疗方法;（3）与Mitchell Ho合作开发CAR-T细胞，将感兴趣的基因递送到肿瘤微环境中;（4）与Rosandra Kaplan合作鉴定骨髓细胞中驱动免疫抑制和肿瘤杀伤的关键基因。这可能有助于改善基于细胞的治疗策略。

The mission of the Center for Cell-based Therapy is to facilitate the discovery and development of cellular immunotherapies for patients with cancer. Two important objectives of this work are: (1) developing approaches to successfully target solid tumors with cell-based immunotherapy, and (2) facilitating collaborative cell-based therapy projects with strong clinical potential. Four areas currently in development for this project are: (1) developing CAR-T Cells targeting GPC2 as a treatment for Neuroblastoma in collaboration with Mitchell Ho, Rosandra Kaplan, and Carol Thiele; (2) creating CAR-T Cells targeting mesothelin as a therapy for mesothelioma and lung adenocarcinoma in collaboration with Mitchel Ho and Ira Pastan; (3) developing CAR-T cells to deliver genes of interest into the tumor micro-environment in collaboration with Mitchell Ho; and (4) identification of key genes driving immune suppression and tumor killing in myeloid cells in collaboration with Rosandra Kaplan. This could potentially facilitate the improvement of cell-based therapy strategies.