Biostatistics and Bioinformatics Core

项目摘要-生物信息学和生物统计学核心C 生物统计学核心是第一个皮肤癌Wistar/UPenn SPORE（2001-2009; 2014-2019年）。核心C功能和与两个校区的皮肤癌研究人员的互动仍然存在 在过去的19年里，这些出版物完好无损，产生了许多高影响力的出版物，报告了以下方面的关键进展： 黑素瘤为了满足项目不断变化的需求和试点项目的预期需求，核心C 已成为生物统计学和生物信息学的核心。核心C关键人员将继续发挥关键作用， 所有实验和临床研究结果的统计设计、统计分析和传播 项目中定义的研究，以及职业提升计划（CEP）和发展 研究计划（DRP）研究活动。该核心成员包括两名高级生物统计学家， 生物信息学家，具有互补的专业知识，与SPORE研究人员进行了广泛的合作， 了解生物统计学和生物信息学方法的新发展及其在研究中的应用 在SPORE中提出，以及广泛的出版记录，反映了他们在黑素瘤和其他 皮肤癌生物统计学家是生物统计部生物统计司的成员。 和流行病学，是阿布拉姆森癌症中心生物统计学共享资源的一部分， 宾夕法尼亚大学。这位生物信息学家是Wistar研究所的教员。生物统计学和 生物信息学核心关键人员将在五个关键领域提供专业知识和经验。一是提供 为研究项目开发的数据集提供强大的计算和数据管理环境， 生物标本和病理学核心（核心B）。二是提供研究方法学方面的专业知识 设计和实施严格的实验室研究、生物标志物研究和临床试验。三是提供 对每个研究项目至关重要的统计方法方面的专门知识。这些活动包括数据计划 大数据发现研究的预处理和分析，测试提出的统计假设以及 建立统计模型。第四是对不同的方法进行评估，以确定 最有效的方法，在标准方法不适用时开发新方法，并进行 使用与研究项目相关的存档公共数据库进行发现研究。五是提供专家 解释研究数据，并与项目调查人员合作， 适当的声明，以及协助编写科学摘要，介绍， 手稿所有核心C的关键人员都在设计这个SPORE中的项目中发挥了重要作用 我们希望在下一个周期的成功中发挥重要作用。

Project Summary – Bioinformatics and Biostatistics Core C The Biostatistics Core has been an integral part of the first Wistar/UPenn SPORE in Skin Cancer (2001-2009; 2014-2019). Core C functionality and interaction with skin cancer researchers on both campuses has remained intact throughout the last 19 years resulting in many high impact publications, reporting key advances in melanoma. To meet the changing needs of the Projects and anticipated needs of the Pilot Programs, Core C has become the Biostatistics & Bioinformatics Core. Core C key personnel will continue to play a critical role in the statistical design, statistical analysis, and dissemination of research results for all experimental and clinical studies defined within the Projects, as well as the Career Enhancement Program (CEP) and Developmental Research Programs (DRP) research activities. The members of this core include two senior biostatisticians and a bioinformatician, who have complementary expertise, extensive collaborations with SPORE investigators, knowledge of new developments in biostatistical and bioinformatics methods and their application to research proposed in the SPORE, and an extensive publication record that reflects their expertise in melanoma and other skin cancers. The biostatisticians are members of the Division of Biostatistics of the Department of Biostatistics and Epidemiology and are part of the Biostatistics Shared Resource of the Abramson Cancer Center at the University of Pennsylvania. The bioinformatician is a faculty member of the Wistar Institute. The Biostatistics and Bioinformatics Core key personnel will provide expertise and experience in five key areas. The first is to provide a robust computational and data management environment for datasets developed by the research projects and the Biospecimen and Pathology Core (Core B). The second is to provide expertise on research methodologies to design and implement rigorous laboratory studies, biomarker studies and clinical trials. The third is to provide expertise on statistical methodologies critical to each research project. These activities include plans for the data preprocessing and analysis for big data discovery studies, testing proposed statistical hypotheses as well as the development of statistical models. The fourth is to conduct evaluations of different methodologies to identify the most effective approach, developing new methods when standard methods are not appropriate, and to conduct discovery studies using archived public databases relevant to the research projects. The fifth is to provide expert interpretation of research data and collaboration with Project investigators to make scientifically and statistically appropriate statements, as well as to assist in the preparation of scientific abstracts, presentations, and manuscripts. All of the Core C key personnel have played a major role in designing the Projects in this SPORE application, and expect to play an instrumental role in the success of the next cycle.