Core C: Biostatistics and Informatics

摘要-生物统计学和生物信息学核心（核心C） 卵巢孢子生物统计学和生物信息学核心提供统计和生物信息学合作 和数据管理支持的每个主要的SPORE项目，发展研究计划 (DRP)和职业提升计划（CEP）项目，以及其他核心。在第1-5年，核心C 成员们在6-10年级继续与SPORE研究人员密切合作，以促进最佳的 研究设计、创建分析计划和解释结果。此外，核心成员还改善了数据 通过将生物标本、临床和动物模型数据库整合为一个 全面的数据管理系统。这种迁移提高了生物统计学的效率 核心成员以及动物模型核心成员、生物标本和患者 登记中心核心成员和研究协调员。该数据库系统不仅被Ovarian 孢子研究人员，但也由机构卵巢癌研究人员。它是一个准确的，最新的 信息，并促进了SPORE内部和内部的合作。成员还制定了一项 改进研究者请求门户网站和SPORE生物标本和核心资源跟踪数据库 请求。 在这次更新中，生物统计学和生物信息学核心将非常积极地准备分析计划， 每个项目。拟议的项目预计将涵盖广泛的方法和分析。的 生物统计学和生物信息学核心将继续确保每位SPORE研究者能够获得统计和 生物信息学专业知识，包括研究设计和分析计划的协作开发， 最先进的数据分析和解释、数据管理资源以及摘要和手稿 准备.此外，核心成员将继续改进现有的数据库基础设施。的 生物统计学和生物信息学核心建立在创新和经过时间考验的程序和系统之上 由马约诊所开发，该诊所是该国最大的统计团体之一，其成员 自1932年以来一直在临床和基础科学研究方面进行合作。这个核心补充和协助 生物样本和患者登记中心以及动物模型中心通过提供优质上级数据所做的努力 生物标本登记处的管理和经验。通过这些合作活动， 生物统计学和生物信息学核心将有助于确保本SPORE的研究以高效， 有效和严格的方式。

ABSTRACT – BIOSTATISTICS AND BIOINFORMATICS CORE (CORE C) The Ovarian SPORE Biostatistics and Bioinformatics Core provides statistical and bioinformatic collaboration and data management support for each of the main SPORE projects, the Developmental Research Program (DRP) and Career Enhancement Program (CEP) projects, and the other Cores. As in Years 1-5, Core C members have continued in Years 6-10 to collaborate heavily with SPORE researchers to facilitate optimal study design, create analysis plans, and interpret results. In addition, Core members also improved the data infrastructure by consolidating the biospecimens, clinical and animal models databases into one comprehensive data management system. This migration has resulted in improved efficiencies for Biostatistics and Bioinformatics Core members as well as Animal Models Core members, Biospecimens and Patient Registry Core members, and study coordinator staff. This database system is utilized not only by Ovarian SPORE researchers, but also by institutional ovarian cancer researchers. It is a source of accurate, up-to-date information and has facilitated both intra- and inter-SPORE collaborations. Members also developed an improved investigator request portal and tracking database for SPORE biospecimen and core resource requests. In this renewal, the Biostatistics and Bioinformatics Core will be very active in preparing the analytical plan for each Project. The proposed projects are expected to span a wide range of approaches and analyses. The Biostatistics and Bioinformatics Core will continue to assure each SPORE investigator access to statistical and bioinformatic expertise that includes collaborative development of study designs and analysis plans, state-of- the-art data analysis and interpretation, data management resources, and abstract and manuscript preparation. In addition, Core members will continue to improve existing database infrastructure. The Biostatistics and Bioinformatics Core builds upon the innovative and time-tested procedures and systems developed by Mayo Clinic, one of the largest statistical groups in the country, whose members have collaborated on clinical and basic science research studies since 1932. This Core complements and assists the efforts of the Biospecimens and Patient Registry Core and Animal Models Core by providing superior data management and experience with biospecimen registries. Through these collaborative activities, the Biostatistics and Bioinformatics Core will help ensure that research in this SPORE is carried out in an efficient, effective, and rigorous manner.