Research Project 3: Intergenerational Transmission of Neuroimmune Vulnerabilities for Addictive Behaviors among African American Youth: A Three Generation Study

项目总结：研究项目3 我们在P50卓越研究中心的背景下提出研究项目3(RP3)： 转化与预防科学(CTAPS)。CTAPS自2003年以来一直得到资助 (P20MH068666；P30DA027827)为推进下一代基础和预防性风险调查， 复原力和生活在资源贫乏社区的非裔美国年轻人中的药物使用 美国东南部。在NIDA神经科学家取得的进展的启发下，我们最近扩大了我们的 考虑到社会逆境对高脂肪/高糖食物消费的影响的计划， 也可以被认为是一种上瘾行为，与毒品一样，它利用了许多相同的神经回路 虐待。了解成瘾行为易损性的形成和预防具有重要意义 对预防药物滥用和心脏代谢性疾病的影响。拟议的P50旨在 通过检测改变对成瘾行为病因和预防的科学认识 神经免疫网络(NIN)模型提出的假设，与家庭和背景相一致 导致吸毒、不健康的饮食习惯和心脏代谢健康的因素 有问题。在RP3中，我们关注的是佐治亚州贫困和失业的农村非裔美国人家庭 这一比例在全国名列前茅。这些家庭中的父母从小就参加了 强大的非裔美国家庭健康青少年/成人项目(SHAPE；R01HD030588)。在RP3中，我们 建议利用SHAPE样本来测试有关行为易上瘾程度的假设 代代相传。我们建议研究多代人的风险和弹性途径 NIN模型建议将慢性自闭症和种族相关压力、父母行为和风险因素联系起来 青春期前儿童的成瘾行为脆弱性和心脏代谢风险。我们将结合现有的 祖父母和父母的数据，目前正在从R01HD030588资助的父母那里收集数据， 并从父母和孩子那里收集这项提案将支持的新数据。我们的首要目标是 调查跨代SES和种族相关压力暴露影响的风险途径 儿童成瘾行为脆弱性与心脏代谢健康。我们的主要终端是儿童的 (~11岁)成瘾行为脆弱性和心脏代谢健康。我们假设暴露在 与自闭症和种族相关的压力源促进了一系列过程，影响了几代人的 易上瘾的行为及其心脏代谢健康。SES通过的机制-- 与种族有关的压力促进儿童成瘾行为的脆弱性和心脏代谢风险包括(A) 使用苛刻、不支持的育儿做法和：(B)非传染性疾病风险因素(炎症和行为--和 情绪调节困难)，以及(C)成瘾行为(父母饮酒， 尼古丁和其他药物，以及他们不健康的饮食。

PROJECT SUMMARY: Research Project 3 We propose Research Project 3 (RP3) in the context of a P50 Research Center of Excellence: The Center for Translational and Prevention Science (CTAPS). CTAPS has been funded continuously since 2003 (P20MH068666; P30DA027827) to advance next-generation basic and preventive investigations of risk, resilience, and drug use among African American young people living in resource-poor communities in the southeastern US. Informed by advances that NIDA neuroscientists have made, we recently expanded our program to consider the influence of social adversity on the consumption of high fat/high sugar foods, which also can be considered an addictive behavior, co-opting many of the same neural circuitries as does drug abuse. Understanding the development and prevention of addictive behavior vulnerabilities has significant implications for preventing both drug abuse and cardiometabolic disease. The proposed P50 is designed to transform scientific understanding regarding the etiology and prevention of addictive behavior by testing hypotheses suggested by a neuroimmune network (NIN) model that, in concert with familial and contextual factors, contributes to the development of drug use, unhealthy eating habits, and cardiometabolic health problems. In RP3, we focus on rural African American families in Georgia in which poverty and unemployment rates are among the highest in the nation. The parents in these families have grown up taking part in the Strong African American Families Healthy Adolescent/Adult Project (SHAPE; R01HD030588). In RP3, we propose to leverage the SHAPE sample to test hypotheses regarding how addictive behavior vulnerabilities are transmitted across generations. We propose to investigate multigenerational risk and resilience pathways linking chronic SES- and race-related stress, parenting behavior, and risk factors suggested by the NIN model to preadolescent children’s addictive behavior vulnerability and cardiometabolic risk. We will combine extant data on grandparents and parents, data currently being collected from parents that R01HD030588 is funding, and collection of new data from parents and children that this proposal will support. Our first aim is to investigate the risk pathways through which SES- and race-related stress exposure across generations affects children’s addictive behavior vulnerabilities and cardiometabolic health. Our primary endpoints are children’s (~age 11) addictive behavior vulnerabilities and cardiometabolic health. We hypothesize that exposure to SES- and race-related stressors promotes a chain of processes generations that affects children’s vulnerabilities to addictive behavior and their cardiometabolic health. The mechanisms through which SES- and race-related stress promote children’s addictive behavior vulnerability and cardiometabolic risk include (a) use of harsh, unsupportive parenting practices and, (b) NIN risk factors (inflammation and behavior- and emotion-regulation difficulties suggested by the NIN model), and (c) addictive behavior (parents’ use of alcohol, nicotine, and other drugs, as well as their unhealthy eating.