Developmental, Contextual, and Psychosocial Predictors of Weathering and Health among Rural African Americans in their Fourth Decade of Life
农村非裔美国人第四个十年风化和健康的发展、背景和社会心理预测因素
基本信息
- 批准号:10665551
- 负责人:
- 金额:$ 58.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1993
- 资助国家:美国
- 起止时间:1993-04-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescenceAdultAffectAfrican AmericanAfrican American populationAgeAgingBehavioralBiologicalBiological AssayBiological MarkersCaucasiansChild RearingChildhoodChronic DiseaseChronic stressClinicalCoronary heart diseaseDataData CollectionDevelopmentDietDisparityDisparity populationDistressEconomicsEducationEmploymentEnvironmentEpigenetic ProcessExhibitsExposure toFamilyHealthHealthcareHormonesIndividualInequalityInflammationInflammatoryInsulin ResistanceInvestigationJointsLeadLifeLife Cycle StagesLife ExpectancyLinkLongevityMediatingMetabolic syndromeMorbidity - disease rateNon-Insulin-Dependent Diabetes MellitusOccupationalOccupationsParticipantPathogenicityPathway interactionsPersonsPhysiologicalPopulationPovertyPreparationProcessProductivityRaceResearchResourcesRiskRisk FactorsRoleRuralRural CommunitySamplingScienceStressStrokeSystemTestingTimeWeatherYouthallostatic loadcardiometabolismcohortcopingdesigndiscountingdisorder riskemerging adulthoodexperiencehuman old age (65+)improvedindexinginnovationneighborhood disadvantagepeerpoor communitiespreadolescencepreventprospectiveprotective factorspsychosocialpublic health researchracial discriminationracial identityresiliencerural African Americansocialsocial determinantsstressorsubstance usevirtualyoung adult
项目摘要
Project Summary
African Americans in the rural South are among the most disadvantaged populations in the US in terms of life
expectancy, a consequence of morbidity from chronic diseases of aging (CDAs). Emerging evidence suggests
that CDAs are conditions that develop over the lifespan, with pathogenic processes starting in childhood but
manifesting clinically at older ages. Wear and tear from chronic stress, beginning in childhood and continuing
throughout the life course, weathers multiple physiological systems, increasing CDA vulnerability. Since 2001,
the Strong African American Families Healthy Adult Project (SHAPE) has followed a cohort of rural African
American youth participating in an investigation of risk, resilience, and development. When participants were
age 19, we expanded our investigations to address biological weathering. We found that exposure to family
economic hardship and racial discrimination in late childhood and adolescence forecast biological weathering
during emerging adulthood as evidenced by allostatic load, inflammatory activity, and epigenetic aging. For
rural African Americans, the fourth decade of life has significant potential to affect biological weathering and
CDA vulnerabilities for better or worse. The influences of poverty, community disadvantage, and racial
discrimination combine to render rural African Americans’ transitions to productive young adult roles especially
challenging and stressful. Despite challenging conditions, many SHAPE participants will maintain in good
health and some may improve their health. During the next 5 years, SHAPE participants will be exposed to
continued and, in some cases, amplified contextual stress. Some participants will evince escalation in their
weathering trajectories and the emergence of health problems, whereas others will not. The proposed research
is designed to investigate the reasons why by collecting two waves of additional data when SHAPE
participants are ages 31 and 33. The data collection will involve biological markers of weathering, indicators of
cardiometabolic health – metabolic syndrome (MetS) and insulin resistance (IR), and developmentally
appropriate behavioral and psychosocial risk and protective factors. Our specific aims are to test hypotheses
regarding: (a) the direct and indirect effects of contextual stressors endemic to rural Southern environments on
indices of weathering and the emergence of MetS and IR, and (b) mechanisms that prevent stress exposure
from affecting rural African American young adults' biological weathering and health. The young adult
protective mechanisms on which we focus include health protective social ties and bonds, problem-focused
coping styles, and protective racial identity.
项目摘要
南方农村的非洲裔美国人是美国生活中最弱势的人群之一
预期,一个结果的发病率从慢性疾病的老龄化(CDAs)。新出现的证据表明
CDA是在整个生命周期中发展的疾病,致病过程始于儿童时期,
临床上表现为老年。从童年开始并持续到现在的长期压力造成的磨损和撕裂
在整个生命过程中,天气多个生理系统,增加CDA的脆弱性。自2001年以来,
强大的非洲裔美国人家庭健康成人项目(SHAPE)跟踪了一组非洲农村的
美国青年参与风险,复原力和发展的调查。当参与者
19岁时,我们扩大了我们的研究,以解决生物风化。我们发现接触家人
童年后期和青春期的经济困难和种族歧视预示着生物风化
在成年初期,如通过非稳态负荷、炎症活动和表观遗传老化所证明的。为
农村非洲裔美国人,生命的第四个十年有显着的潜力,影响生物风化,
CDA漏洞是好是坏。贫困、社区弱势和种族歧视的影响
歧视联合收割机使农村非洲裔美国人向生产性青年角色的过渡,
充满挑战和压力尽管条件具有挑战性,但许多SHAPE参与者将保持良好的
有些人可以改善他们的健康。在未来5年内,SHAPE参与者将接触到
持续的,在某些情况下,放大了上下文压力。一些参与者会表现出他们的升级,
风化轨迹和健康问题的出现,而其他人则不会。拟议研究
旨在通过收集两波附加数据来调查SHAPE时
参加者年龄分别为三十一岁及三十三岁。数据收集将涉及风化的生物标志物、
心脏代谢健康-代谢综合征(MetS)和胰岛素抵抗(IR),
适当的行为和心理社会风险和保护因素。我们的具体目标是检验假设
关于:(a)南方农村环境特有的环境压力因素对
风化指数和MetS和IR的出现,以及(B)防止应力暴露的机制
影响农村非洲裔美国年轻人的生物风化和健康。年轻的成人
我们关注的保护机制包括健康保护性社会联系和纽带、以问题为中心
应对方式和保护性种族认同
项目成果
期刊论文数量(81)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Oxytocin Receptor Genetic and Epigenetic Variations: Association With Child Abuse and Adult Psychiatric Symptoms.
- DOI:10.1111/cdev.12493
- 发表时间:2016-01
- 期刊:
- 影响因子:4.6
- 作者:Smearman EL;Almli LM;Conneely KN;Brody GH;Sales JM;Bradley B;Ressler KJ;Smith AK
- 通讯作者:Smith AK
The development of conventional sexual partner trajectories among african american male adolescents.
- DOI:10.1007/s10508-012-0025-5
- 发表时间:2013-07
- 期刊:
- 影响因子:3.8
- 作者:Kogan, Steven M.;Yu, Tianyi;Brody, Gene H.;Allen, Kimberly A.
- 通讯作者:Allen, Kimberly A.
Protective Prevention Effects on the Association of Poverty With Brain Development.
- DOI:10.1001/jamapediatrics.2016.2988
- 发表时间:2017-01-01
- 期刊:
- 影响因子:26.1
- 作者:Brody, Gene H.;Gray, Joshua C.;Yu, Tianyi;Barton, Allen W.;Beach, Steven R. H.;Galvan, Adrianna;MacKillop, James;Windle, Michael;Chen, Edith;Miller, Gregory E.;Sweet, Lawrence H.
- 通讯作者:Sweet, Lawrence H.
The Great Recession and health risks in African American youth.
- DOI:10.1016/j.bbi.2015.12.015
- 发表时间:2016-03
- 期刊:
- 影响因子:0
- 作者:Chen E;Miller GE;Yu T;Brody GH
- 通讯作者:Brody GH
Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies.
- DOI:10.1097/ypg.0b013e3283208026
- 发表时间:2009-04
- 期刊:
- 影响因子:0.9
- 作者:Philibert RA;Gunter TD;Beach SR;Brody GH;Hollenbeck N;Andersen A;Adams W
- 通讯作者:Adams W
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Katherine Babcock Ehrlich其他文献
Katherine Babcock Ehrlich的其他文献
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{{ truncateString('Katherine Babcock Ehrlich', 18)}}的其他基金
Research Project 3: Intergenerational Transmission of Neuroimmune Vulnerabilities for Addictive Behaviors among African American Youth: A Three Generation Study
研究项目 3:非洲裔美国青少年成瘾行为的神经免疫脆弱性的代际传递:一项三代研究
- 批准号:
10455003 - 财政年份:2020
- 资助金额:
$ 58.22万 - 项目类别:
Research Project 3: Intergenerational Transmission of Neuroimmune Vulnerabilities for Addictive Behaviors among African American Youth: A Three Generation Study
研究项目 3:非洲裔美国青少年成瘾行为的神经免疫脆弱性的代际传递:一项三代研究
- 批准号:
10240671 - 财政年份:2020
- 资助金额:
$ 58.22万 - 项目类别:
Research Project 3: Intergenerational Transmission of Neuroimmune Vulnerabilities for Addictive Behaviors among African American Youth: A Three Generation Study
研究项目 3:非洲裔美国青少年成瘾行为的神经免疫脆弱性的代际传递:一项三代研究
- 批准号:
10023726 - 财政年份:2020
- 资助金额:
$ 58.22万 - 项目类别:
Research Project 3: Intergenerational Transmission of Neuroimmune Vulnerabilities for Addictive Behaviors among African American Youth: A Three Generation Study
研究项目 3:非洲裔美国青少年成瘾行为的神经免疫脆弱性的代际传递:一项三代研究
- 批准号:
10670904 - 财政年份:2020
- 资助金额:
$ 58.22万 - 项目类别:
Parental Depression and the Early Origins of Disease Across Three Generations.
父母抑郁症和三代人疾病的早期起源。
- 批准号:
9754224 - 财政年份:2018
- 资助金额:
$ 58.22万 - 项目类别:
Parental Depression and the Early Origins of Disease Across Three Generations.
父母抑郁症和三代人疾病的早期起源。
- 批准号:
9599710 - 财政年份:2018
- 资助金额:
$ 58.22万 - 项目类别:
Adolescent Social Relationships and Immune, Endocrine, and Metabolic Processes
青少年社会关系与免疫、内分泌和代谢过程
- 批准号:
8643092 - 财政年份:2013
- 资助金额:
$ 58.22万 - 项目类别:
Adolescent Social Relationships and Immune, Endocrine, and Metabolic Processes
青少年社会关系与免疫、内分泌和代谢过程
- 批准号:
8525844 - 财政年份:2013
- 资助金额:
$ 58.22万 - 项目类别:
Parent-Adolescent Relationships, Distress Tolerance, and Adolescent HIV-Risk
父母与青少年的关系、痛苦耐受性和青少年艾滋病毒风险
- 批准号:
7920915 - 财政年份:2009
- 资助金额:
$ 58.22万 - 项目类别:
Parent-Adolescent Relationships, Distress Tolerance, and Adolescent HIV-Risk
父母与青少年的关系、痛苦耐受性和青少年艾滋病毒风险
- 批准号:
8123221 - 财政年份:2009
- 资助金额:
$ 58.22万 - 项目类别:
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