Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

爱因斯坦内森冲击中心（E-NSC）已经发展到包括内部（46）和外部（33）成员 参与有意义的合作和项目，并接受P&F支持。这种增长 伴随着令人印象深刻的出版记录E-NSC成员，例如124篇论文， 在《自然》、《细胞》和《科学》杂志上发表评论，平均约有5篇合作论文， (with其他E-NSC成员），并积极招募和“转换”许多 在以前提交的报告中不是成员的欧洲国家安全委员会成员。其他资源也很重要 对于E-NSC的成功，包括大型老龄化项目（P01和U赠款），正在进行的NIH资助的爱因斯坦老龄化 (T32)培训补助金，关于衰老生物学的补充研究生课程，以及资助的资源 爱因斯坦·格伦人类衰老生物学中心（Einstein Glenn Center for Biology of Human Aging）欧洲国家安全理事会的活动包括： 通过补充机构资金的杠杆作用;该中心授予了26个试点和可行性赠款， 结果。这三个研究资源中心为167名研究人员提供了服务， 以合理的价格提供可靠的质量控制服务。E-NSC的（简略）目标是： 通过提供尖端技术来加强和扩大正在进行的衰老生物学研究 和创新的方法，通过服务（不包括啮齿动物的健康跨度）不存在于其他NSC： a）衰老核心蛋白质稳定（PAC）（Cuervo）将继续提供分析、试剂和专业知识 用于分析衰老过程中的蛋白质稳态。PAC创新部门将继续开发和实施 研究人类衰老蛋白质稳态的方法学。它现在包括药物开发咨询 的服务. B）健康跨度核心（HSC）（霍夫曼）将继续提供复杂的综合研究 用于确定健康衰老生理学和用于共生研究的资源。（三）人类多组学 核心（HMOC）（Vijg）将增加计划和执行单细胞表观/基因组学分析的服务，以解决 衰老生物学中的重要问题它将提供组学数据（全外显子组测序，aftamer蛋白质组学 数据，转录组学和代谢组学）。（2）计划和 协调老年科学活动，促进合作，整合研究中心的活动， 爱因斯坦和其他机构的研究成果。行政核心（Barzilai/Cuervo）将继续 通过研讨会、小型务虚会和国家安全委员会国家会议，实施和促进充实活动， 以及开发资源，以促进参与机构老龄化研究的团体的整合， 有限的老龄问题研究支持;核心小组还确保对电子国家安全中心服务进行广泛宣传。目标3） 提供支持和环境，有利于促进蓬勃发展的生物学新的研究人员， 通过研发中心（Milman/Singh）老化。我们将提供P&F奖励和指导， 新的老龄化研究人员和其他正在进行的令人兴奋的研究计划的扩展/分歧的支持。

The Einstein Nathan Shock Center (E-NSC) has grown to includes internal (46) and external (33) members who are engaged in meaningful collaborations and programs and are recipients of P&F support. This growth was accompanied by an impressive publication record E-NSC members as exemplified in 124 papers and reviews in Nature, Cell and Science journals, a staggering average of approximately five collaborative papers (with other E-NSC members) per E-NSC investigator and the proactive recruitment and ‘conversion’ of many members to the E-NSC who were not members for previous submissions. Other resources are also important for E-NSC success, including large aging programs (P01 and U grants), an ongoing NIH-funded Einstein Aging (T32) training grant, a complementary graduate course on the Biology of Aging, and resources from funded projects through the Einstein Glenn Center for Biology of Human Aging. Activities of the E-NSC were leveraged by supplemental Institutional funding; the Center awarded 26 pilot and feasibility grants, with good outcomes. The three Research Resource Cores provided services to 167 investigators, offering state-of the art services with dependable quality control at an affordable price. The (abridged) aims of the E-NSC are: Aim 1) To enhance and expand ongoing biology of aging research by providing access to cutting-edge technology and innovative approaches through services that (excluding health span of rodents) do not exist in other NSCs: a) The Proteostasis of Aging Core (PAC) (Cuervo) will continue to provide assays, reagents and expertise for the analysis of proteostasis in aging. The PAC Innovation Unit will continue developing and implementing methodologies for the study of human aging proteostasis. It now includes a drug development consulting service. b) The Health Span Core (HSC) (Huffman) will continue to provide sophisticated integrative studies for determination of healthy aging physiology and resources for parabiosis studies. c) The Human Multi-omics Core (HMOC) (Vijg) will add services for planning and executing single cell epi/genomics analyses to address important problems in biology of aging. It will provide omic data (whole exome sequencing, aftamer proteomic data, transcriptomic and metabolomic) from well phenotyped human aging data. Aim 2) To plan and coordinate geroscience activities, foster collaborations and integrate activities of the Research Cores and research efforts at Einstein and other institutions. The Administrative Core (Barzilai/Cuervo) will continue implementing and promoting enrichment activities through seminars, mini-retreats and NSC national meetings, and developing resources to facilitate integration of groups engaged in aging research at institutions with limited aging research support; the Core also ensure that E-NSC services are well publicized. Aim 3) To provide support and an environment conducive to promotion of thriving new investigators in biology of aging through a Research Development Core (Milman/Singh). We will provide P&F awards and mentoring to new aging researchers and support for expansion/divergence of other ongoing exciting research programs.