Alterations and Renovations

改造与改造 项目摘要/摘要 翻译听力中心(THC)建立了两个功能核心：药物 发现和交付核心(DDDC)和听觉和前庭技术核心(AVTC) 促进和加强听力损失治疗学的翻译研究。目前所有核心 设施和设备位于克雷顿大学核心附近或其内部 在Criss I/II/III建筑群中的设施，以及位于 邻近机构：内布拉斯加大学医学中心(UNMC)和男孩镇 国立研究医院(BTNRH)。进一步增强我们为研究项目提供的服务 领导(RPL)和中心调查人员，我们计划通过以下方式使我们的设施与我们的实力保持一致 在第一年内通过翻新现有实验室创造新的实验室空间 科布尔奖。促进有效的化学合成和分析，并促进新的 先进的成像，我们寻求翻新药物化学实验室Criss II 326和一个新的 听力测试实验室Criss I 304的空间。随着这些改造项目的完成， THC将为每个核心建立新的集中式实验室。这些可以很容易地进一步 扩建并整合到克雷顿大学核心设施中。这些都将显著地 加强我们在建议书中概述的服务。

ALTERATION & RENOVATION Project Summary/Abstract The Translational Hearing Center (THC) has established two functional cores: The Drug Discovery & Delivery Core (DDDC) and Auditory & Vestibular Technology Core (AVTC) to promote and enhance translational research on therapeutics for hearing loss. Currently all core facilities and equipment are located in close proximity to or within the Creighton University Core Facilities in the Criss I/II/III building complex, with additional satellite AVTCs located in neighboring institutions: University of Nebraska Medical Center (UNMC) and Boys Town National Research Hospital (BTNRH). To further empower our services for the Research Project Leaders (RPLs) and Center Investigators, we plan to align our facilities with our strength by creating new laboratory spaces through renovation of existing laboratories within first year of the COBRE award. To facilitate efficient chemical synthesis and analysis and facilitate new advanced imaging, we seek to renovate medicinal chemistry laboratory Criss II 326 and a new space for auditory hearing test laboratory Criss I 304. With these renovation projects completed, THC will have new, centralized laboratories for each core. These can be easily further expanded and integrated into the Creighton University Core Facilities. These will significantly enhance our services outlined in our proposal.