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Translational Hearing Center

转化听力中心

基本信息

批准号：
10579956
负责人：
Peter Stephen Steyger
金额：
$ 211.6万
依托单位：
CREIGHTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-05 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10579956
关键词：
Academic Medical Centers Academic achievement Acceleration Achievement Address Admission activity Advisory Committees Affect Aging Attenuated Auditory Auditory Perception Award Basic Science Biological Assay Biomedical Research Biometry Center for Translational Science Activities Centers of Research Excellence Child Cities Clinical Clinical Investigator Clinical Research Clinical Trials Complement Development Drug Delivery Systems Drug Prescriptions Drug Screening Economic Burden Eligibility Determination Ensure Environment Etiology Evaluation Research Exposure to Fetal Alcohol Spectrum Disorder Fostering Foundations Functional disorder Funding Funding Mechanisms Future Genetic Polymorphism Genomics Goals Grant Great Plains Health Health system Hearing Hearing problem Hospitals Human Impaired cognition Income Individual Infant Inflammation Infrastructure Institution International Intervention Investigation Investigational Drugs Investigational New Drug Application Labyrinth Language Lead Life Longevity Malignant Neoplasms Medical Medical center Mental Depression Mentors Mentorship Military Personnel Mitochondria Multicenter Studies Nebraska Neonatal Intensive Care Units Neural Pathways Noise Noise-Induced Hearing Loss Occupational Peripheral Persons Pharmacologic Substance Phase Pilot Projects Population Production Quality of life Recreation Rehabilitation therapy Research Research Activity Research Personnel Research Project Grants Risk Secure Sensory Services Social Interaction Study Section System Technology Therapeutic Therapeutic Intervention Translating Translational Research Translations Universities Withdrawal aging population base boys candidate identification candidate validation career cisplatin induced hearing loss clinical center drug discovery efficacy study efficacy validation fall risk hearing impairment hearing loss phenotype hearing loss risk hearing preservation hearing restoration high risk lead candidate multidisciplinary neonate ototoxicity patient population pharmacologic preclinical study preservation programs psychosocial recruit safety study skills social socioeconomics success therapeutic candidate translational scientist voucher working group

项目摘要

PROJECT SUMMARY/ABSTRACT Overall Plan for the Translational Hearing Center This Center of Biomedical Research Excellence (COBRE) application is to establish the Translational Hearing Center, administered by centrally-located Creighton University, with Boys Town National Research Hospital (BTNRH) and the University of Nebraska Medical Center (UNMC), as institutional partners. Our overall goal is to build a critical mass of academic translational researchers developing therapeutic interventions to preserve or restore hearing and vestibular function from a wide range of etiologies that cause hearing loss and vestibular deficits. Hearing loss in infants and children results in delayed acquisition of listening and spoken language skills critical for academic achievement and maximal career trajectories of affected individuals. In the aging population, hearing loss and vestibular deficits without appropriate rehabilitation accelerates aging and cognitive decline. Aim 1: Develop the infrastructure and expertise base for translational auditory and vestibular research. COBRE funding will enable an Administrative Core within the Center to provide a unique, transformational research environment for junior investigators to translate their basic science discoveries into therapeutic strategies that preserve or restore hearing and vestibular function. This will establish a broader nonclinical research program. The Administrative Core will coordinate interactions between project leaders with their Mentors, and an External Advisory Committee. The Administrative Core will develop a Drug Discovery and Delivery Core that will coordinate necessary drug screen assays and production of derivatives of lead compounds and their delivery to the inner ear and associated central neural pathways, as well as an Auditory Vestibular Technology Core to validate the efficacy of lead candidate ototherapeutics hits. Aim 2: Build a critical mass of funded investigators leading translational auditory and vestibular research. We will examine both peripheral and central mechanisms of hearing loss and vestibular dysfunction, and identify pharmacotherapeutic strategies preserve or restore hearing and vestibular function, with multiple levels of research funding for investigators. We also have an outstanding Mentoring Plan for project leaders, complementing their expertise with senior investigations as Internal Mentors and biostatistical support, as well as outside investigators with translational and clinical expertise as External Mentors. Additional mentoring is provided by Research Core staff, grantsmanship classes and Mock Study Sections of proposals prior to review. Evaluations of research progress, and all other Center activities, are also key to optimize Center success. The Center will also benefit from the burgeoning translational research environment in Omaha, Nebraska. Future plans call for continued expansion of the Center to include submission of Investigational New Drug applications, safety and efficacy studies and clinical trials in partnership with patient populations served by Creighton University’s academic medical center, Catholic Health Initiatives (CHI) Health system, BTNRH and UNMC.

项目总结/文摘