University of New Mexico Center for Metals in Biology and Medicine - equipment supplement

无机金属长期以来一直是新墨西哥州生物医学研究的重点，因为 该地区与采矿有关的金属污染物。在新墨西哥大学金属生物学中心 和医学(UNM CMBM)我们的主要重点将是研究不良健康后果(包括 癌症、肺、神经和其他疾病)金属污染物以及利用 用于治疗和营养目的的金属的化学性质。详细的分子知识 金属物种和生物分子之间的相互作用可能导致临床和种群水平的干预 以改善公众健康。虽然重金属和过渡金属在医学和毒物学上都显示出 但是，分子和细胞之间的相互作用往往没有得到充分的了解。UNM CMBM 将结合无机化学、分析化学和金属混合物毒理学方面的专业知识来添加 对指导型首席调查员(MPI)研究的成熟度和翻译价值。近期 导师团队成员和MPI的发现突显了对分子更深层次研究的需要 在研究金属与生物分子靶的相互作用方面的探索，如这种详细的理解允许 改进受体靶向(在药物方面)或创新干预措施(在药物方面 环境危害)。通过提供智力专业知识和先进的仪器设备来帮助MPI 在研究方面，我们将增加他们的资助机会和事业发展，使其完全独立。 我们项目中的导师在成功的初级教师职业发展方面有着深厚的历史，我们 将通过促进多学科的关键概念，在P20中心的框架内进一步加强 团队科学和翻译研究方法。我们的长期目标是建立一个全国性的 资金雄厚的研究人员开展金属毒理学创新研究的认可计划 对新墨西哥和西南部社区有积极影响的生物医学。我们将实现这一目标 通过以下三个具体目标实现目标：目标1.建立一个强大的独立调查人员社区 具有与医学和生物学中的金属相关的共同研究目标。目标2.建立集中研究 整合现有UNM-Health Science Center(HSC)的综合分子分析核心设施 科学资源和创新设施建设，以改善生物分析化学研究培训和 为了提高MPI的生产率，以及提高我们研究所的研究质量和深度。目标3.创建独一无二的 《生物医学中的金属》课程具有明确的T0-T4翻译价值。成功者 该中心的实施将导致UNM独立研究资金的增长，特别是在 初级调查员实现独立的职业目标。我们计划的结果具有明确的临床和 公共卫生惠及西南部人口和社区，包括众多土著居民 美国人口受到采矿作业遗留废物的不成比例的影响。 1

Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) our main focus will be on both studying adverse health outcomes (including cancer, pulmonary, neurologic, and other disorders) of metal contaminants as well as on harnessing the chemical properties of metals for therapeutic and nutritional purposes. Detailed knowledge of molecular interactions between metallic species and biomolecules can lead to clinical and population-level interventions to improve public health. While heavy and transition metals exhibit both medical and toxicological characteristics, the molecular and cellular interactions are often inadequately understood. The UNM CMBM will combine expertise in inorganic chemistry, analytical chemistry, and metal mixtures toxicology to add sophistication and translational value to the research of mentored principal investigators (mPIs). Recent discoveries from members of the mentorship team and mPIs highlight the need for greater depth of molecular inquiry in studying metal interactions with biomolecular targets, as such detailed understanding permits improvements in receptor targeting (in the case of medicines) or innovative interventions (in the case of environmental hazards). By providing intellectual expertise and advanced instrumentation to aid the mPIs' research endeavors, we will enhance their funding opportunities and career progression to full independence. The mentors in our program have a strong history of successful junior faculty career development, which we will further enhance within the framework of this P20 Center by promoting the key concepts of multidisciplinary team science and translational research approaches. Our long-term goal is to establish a nationally recognized program of well-funded researchers conducting innovative research on metals toxicology and biomedicine that has positive impacts on New Mexican and Southwestern communities. We will achieve this goal through the following three specific aims: Aim 1. Create a strong community of independent investigators with common research goals related to metals in medicine and biology. Aim 2. Establish centralized research Integrative Molecular Analysis Core Facility by integrating existing UNM-Health Science Center (HSC) scientific resources and building innovative facilities to improve bioanalytical chemistry research training and productivity for mPIs, as well as to bolster research quality and depth for our institute. Aim 3. Create a unique “Metals in Biology and Medicine” program that has clear T0-T4 translational value. The successful implementation of this Center will lead to growth in independent research funding at UNM, especially among junior investigators achieving independent career goals. The outcomes of our program have clear clinical and public health benefit to populations and communities in the southwest, including the numerous Native American populations disproportionately impacted by legacy waste from mining operations. 1