Enhancement of neural regeneration

项目摘要/摘要 具有再生能力的生物已经成为揭示自然机制的信息模型 哪种神经系统损伤会激活干细胞或祖细胞进行损伤修复。时间、地点和 损伤的程度不是预先确定的，需要存在指导组织修复的机制 完美对抗损害影响的活动。理解这一过程的一个关键问题是如何 停止再生性增长是成功的。要开始解决这个问题，必须定义 转录和细胞信号系统，负向调节成人再生神经发生。而当 再生组织已经被广泛探索为再生的积极调节者，但知之甚少。 关于起相反作用的因素，以及其抑制可能导致神经再生增强的因素。在 这笔赠款的目的是通过利用脊椎动物系统的专业知识来解决这一赤字问题，该系统具有独特的 允许进入完全成人大脑再生的生物学。揭示保守的和基本的 生物体用来限制组织再生和细胞周转的程度和速度的机制将提供 对理解和最终治疗疾病的基本见解，其特征是无法 接受充分的神经修复。

Project Summary/Abstract Organisms with regenerative abilities have been informative models for uncovering natural mechanisms by which nervous system damage activates stem or progenitor cells for injury repair. The timing, location, and extent of injuries are not predetermined, requiring the existence of mechanisms that instruct tissue restoration activities that perfectly counter the effects of damage. A key question to understand this process is how cessation of regenerative growth is accomplished. To begin to address this question, it is essential to define the transcriptional and cell signaling systems that negatively regulate adult regenerative neurogenesis. While regenerative tissues have been extensively probed for positive regulators of regeneration, much less is known about factors that act in opposition and whose inhibition could lead to enhanced neural regeneration. In the aims of this grant, this deficit is addressed by leveraging expertise in the planarian system, which uniquely allows access to the biology of complete adult brain regeneration. Uncovering the conserved and fundamental mechanisms used by organisms to limit the extent and rate of tissue regeneration and cell turnover will provide foundational insights into understanding and ultimately treating diseases characterized by an inability to undergo sufficient neural repair.