Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System Equipment Supplement

项目摘要 我们第一阶段生物研究卓越中心(COBRE)的总体目标是 建立心血管分子和细胞信号转导的内华达眼镜蛇 内华达大学雷诺分校(UNR)和UNR医学院(UNR Med)的系统 作为一个可持续的、专题的、跨学科的基础科学研究中心。这项任务将是 通过开发和利用最先进的分子、遗传、生物物理和 生物医学成像技术。Cobre由一个管理核心(核心A)组成 由项目主任Scott Earley博士、两个研究核心和五个项目负责人领导。 冯玉梅博士是转基因动物基因分型和表型分型中心主任 核心(TAGP，核心B)和诺曼德·勒布朗博士指导了高空间和时间分辨率 映像核心(HSTRI；核心C)，为项目负责人提供访问广泛阵列的途径 最先进的仪器使细胞和细胞的高空间和时间分辨率成像 用荧光指示剂标记的组织样本。科布雷正在提交一份申请 回应NOSI NOT-GM-22-017的行政补编，将加强 TAGP核心的功能。此应用程序的具体目标是购买新的EchoMRI 机器。这个新系统的标价是167,500美元。EchoMRI允许进行非侵入性、 活体动物脂肪量、瘦肉量、游离水和全身水的高精度检测， 这是TAGP核心目前没有的功能。带着谁动物的需求 心血管和代谢表型，该系统将提供新的创新技术 项目负责人以及中心和其他UNR生物医学中心的现有成员 调查人员。按照配置，该EchoMRI具有执行精确测量的能力 整个动物的体重在25-500克之间。该系统还配备了用于活检的天线/探头 和组织检查。

Project Summary The overall objective of our Phase I Center of Biological Research Excellence (COBRE) is to establish the Nevada COBRE in Molecular and Cellular Signal Transduction in the Cardiovascular System at the University of Nevada, Reno (UNR) and the UNR School of Medicine (UNR Med) as a sustainable, thematic, interdisciplinary basic science research Center. This mission will be accomplished by developing and utilizing state-of-the-art molecular, genetic, biophysical, and biomedical imaging technologies. The COBRE comprises an Administration Core (Core A) headed by the Program Director, Dr. Scott Earley, two Research Cores, and 5 Project Leaders. Dr. Yumei Feng Earley is the Director of the Transgenic Animal Genotyping and Phenotyping Core (TAGP, Core B) and Dr. Normand Leblanc directs the High Spatial and Temporal Resolution Imaging Core (HSTRI; Core C), which provides the Project Leaders with access to a wide array of state-of-the-art instruments enabling high spatial and temporal resolution imaging of cells and tissues samples labeled with fluorescent indicators. The COBRE is submitting an application for an Administrative Supplement in response to NOSI NOT-GM-22-017 that will enhance the capabilities of the TAGP Core. The Specific Aim of this application is to purchase a new EchoMRI machine. The price tag for this new system is $167,500. The EchoMRI allows for a non-invasive, high precision examination of fat-mass, lean-mass, free-water and total body water in live animals, a capability that the TAGP Core currently does not have currently. With the demand of who animal cardiovascular and metabolic phenotyping, this system will provide new innovative techniques to the Project leaders as well as the established members of the center and other UNR biomedical investigators. As configurated, this EchoMRI has the capacity to perform precise measurement of whole animals range from 25-500g. This system is also equipped with antenna/probe for biopsy and tissue examination.