Optimization of a personalized skin cancer risk intervention for at-risk young adults

项目总结 黑色素瘤和非黑色素瘤皮肤癌在年轻人中很常见。年轻人把自己放在 由于晒黑习惯和不一致地使用推荐的防晒措施，皮肤癌的风险增加 方法：研究方法。现有的针对年轻人的干预措施依赖于一刀切的方法，主要是使用 关注外表的上诉审查短期结果，而没有审查潜在的调解人 干预效果。我们为大学生设计了皮肤癌预防干预措施，其中包括 不同类型的个性化皮肤癌风险信息(显示潜在皮肤损害的紫外线照片， MC1R测试表明皮肤癌的遗传风险，行动计划)以增加对个性化的接受 风险信息，并促进减少晒黑和增加使用防晒。我们的研究是以 细化可能性模型；因此，我们假设干预组件将通过以下方式改善结果 增加高度与个人相关的风险和行为规划信息的中央处理。在我们的 对这些干预成分的初步研究，我们观察到晒黑行为和 干预前后防晒能力的提高。我们建议应用多阶段优化策略 确定建议的哪些成分或它们的组合最佳地防止晒伤，以及 其次，在大学生中，哪些元素不利于晒黑并增加防晒霜的使用？ 较长时间间隔(12个月以上)。通过一个完全析因实验，我们将检验三个因素的影响 个性化风险组件：1)紫外线照片；2)MC1R基因检测结果；3)行动计划。我们会 探索干预效果的社会人口学和行为调节因素，以便向 制定未来深度定制、优化的适应性干预措施。该项目解决了关键的 需要对大学环境中的年轻人进行有效的皮肤癌预防干预。该项目将 也导致了对主持人干预效果的新的科学认识，这将导致更多 深度定制的干预措施，更好地满足所有年轻人的需求。

PROJECT SUMMARY Melanoma and non-melanoma skin cancers are common among young adults. Young adults put themselves at increased risk for skin cancers due to their tanning habits and inconsistent use of recommended sun protection methods. Existing interventions for young adults have relied on a one-size-fits-all approach primarily using appearance-focused appeals examining short-term outcomes, and have not examined potential moderators of intervention effects. We designed a skin cancer prevention intervention for college students that incorporates different types of personalized skin cancer risk information (ultraviolet photo showing underlying skin damage, MC1R testing indicating genetic risk for skin cancer, action planning) to increase receptivity to personalized risk information and to facilitate decreased tanning and increased use of sun protection. Our study is guided by the Elaboration Likelihood Model; as such we posit that intervention components will improve outcomes by increasing central processing of highly personally relevant risk and behavioral planning information. In our preliminary studies of these intervention components, we observed decreases in tanning behaviors and increases in sun protection pre- to post-intervention. We propose to apply a Multiphase Optimization Strategy to identify which of the proposed components or their combinations optimally prevent sunburn, and secondarily, which elements discourage tanning and increase use of sun protection in college students over longer term intervals (12+ months). Through a full factorial experiment, we will examine the effects of three personalized risk components: 1) UV photo; 2) MC1R genetic testing results; 3) action planning. We will explore socio-demographic and behavioral moderators of the intervention effects in order to inform the development of future deeply-tailored, optimized adaptive interventions. This project addresses the critical need for efficacious skin cancer preventive interventions for young adults in the college setting. The project will also lead to new scientific understanding of moderators of the intervention effects, which will lead to more deeply tailored interventions that better meet the needs of all young adults.