Perception of Gene-Environment Cancer Risks in Melanoma

对黑色素瘤基因环境癌症风险的认识

基本信息

  • 批准号:
    6799320
  • 负责人:
  • 金额:
    $ 13.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-09-08 至 2008-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this career development application is to launch an independent research program on perception of gene-environment cancer risks. There is mounting evidence that common genetic polymorphisms can either accentuate or attenuate environmental risks, such as smoking and sun exposure, and that these interactions are a primary etiological pathway to carcinogenesis. In the coming years, it is likely that a growing number of individuals will receive probabilistic information concerning genetic and environmental cancer risk factors. The number of individuals who are affected will exceed those with uncommon, highly penetrant single-gene mutations. Existing research on cancer risk communication targeted to those with single risk factors, such as genetic mutations alone, or lifestyle risk factors alone, do not adequately address the potential challenges and prevention opportunities presented by our increasingly comprehensive understanding of environmental and genetic risk interactions. Gene-environment interactions are implicated in the etiology of a number cancer sites. Melanoma will provide the paradigm for study in this application because of the evidence for gene-environment etiology, rising incidence rates, and promise of behavioral prevention. Given the current absence of identified germ line mutations, studying first-degree relatives of melanoma patients will provide a vehicle in the proposed studies to examine the role of gene-environment risk perceptions and both skin cancer screening and sun protection behavior. Study I is a qualitative interview study of risk perceptions among first-degree relatives of melanoma patients. Study II is a prospective assessment of risk perceptions, skin cancer screening, and sun protection behaviors among first degree-relatives of recently diagnosed melanoma patients. Through intensive interaction with multidisciplinary colleagues, formal epidemiology coursework, teaching, and research, this career development award will establish my multidisciplinary research skills at the interface of genetic epidemiology and behavioral science, and position me to establish novel theory and measurement strategies for the role of risk perceptions of gene-environment interactions, and ultimately to develop communication models of gene-environment cancer risks which will be applicable to other cancer sites.
描述(由申请人提供):本职业发展申请的总体目标是启动一个关于基因环境癌症风险感知的独立研究项目。越来越多的证据表明,常见的遗传多态性可以加重或减轻环境风险,如吸烟和日晒,这些相互作用是致癌的主要病因途径。在未来的几年里,可能会有越来越多的人收到有关遗传和环境癌症风险因素的概率信息。受影响的个体数量将超过那些罕见的、高渗透的单基因突变。现有的癌症风险交流研究针对的是那些有单一风险因素的人,比如单独的基因突变,或者单独的生活方式风险因素,并没有充分解决我们对环境和遗传风险相互作用的日益全面的理解所带来的潜在挑战和预防机会。基因-环境相互作用与许多癌症部位的病因学有关。黑色素瘤将为这一应用的研究提供范例,因为有证据表明基因-环境病因,发病率上升,以及行为预防的前景。鉴于目前没有确定的生殖系突变,研究黑色素瘤患者的一级亲属将为拟议的研究提供一种工具,以检查基因-环境风险感知和皮肤癌筛查和防晒行为的作用。研究一是对黑色素瘤患者一级亲属风险认知的定性访谈研究。研究二是对近期确诊黑色素瘤患者一级亲属的风险认知、皮肤癌筛查和防晒行为进行前瞻性评估。通过与多学科同事的密切互动,正式的流行病学课程,教学和研究,这个职业发展奖项将在遗传流行病学和行为科学的界面上建立我的多学科研究技能,并使我能够为基因-环境相互作用的风险感知的作用建立新的理论和测量策略。并最终建立适用于其他癌症部位的基因-环境癌症风险沟通模型。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

JENNIFER L HAY其他文献

JENNIFER L HAY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('JENNIFER L HAY', 18)}}的其他基金

Optimization of a personalized skin cancer risk intervention for at-risk young adults
针对高危年轻人的个性化皮肤癌风险干预措施的优化
  • 批准号:
    10582944
  • 财政年份:
    2023
  • 资助金额:
    $ 13.43万
  • 项目类别:
Psychosocial Palliative and Community Research in Cancer
癌症的社会心理姑息治疗和社区研究
  • 批准号:
    10686344
  • 财政年份:
    2019
  • 资助金额:
    $ 13.43万
  • 项目类别:
"Don't Know" Responses to Risk Perception Questions: Identifying Mechanisms and Solutions
对风险认知问题的“不知道”回答:确定机制和解决方案
  • 批准号:
    8945410
  • 财政年份:
    2015
  • 资助金额:
    $ 13.43万
  • 项目类别:
"Don't Know" Responses to Risk Perception Questions: Identifying Mechanisms and Solutions
对风险认知问题的“不知道”回答:确定机制和解决方案
  • 批准号:
    9126471
  • 财政年份:
    2015
  • 资助金额:
    $ 13.43万
  • 项目类别:
Measuring real time decision-making about UVR Protection
测量有关 UVR 防护的实时决策
  • 批准号:
    7739952
  • 财政年份:
    2009
  • 资助金额:
    $ 13.43万
  • 项目类别:
Cancer Risks Beliefs & Screening
癌症风险信念
  • 批准号:
    7589131
  • 财政年份:
    2009
  • 资助金额:
    $ 13.43万
  • 项目类别:
Cancer Risks Beliefs & Screening
癌症风险信念
  • 批准号:
    7748010
  • 财政年份:
    2009
  • 资助金额:
    $ 13.43万
  • 项目类别:
Perception of Gene-Environment Cancer Risks in Melanoma
对黑色素瘤基因环境癌症风险的认识
  • 批准号:
    7278234
  • 财政年份:
    2003
  • 资助金额:
    $ 13.43万
  • 项目类别:
Perception of Gene-Environment Cancer Risks in Melanoma
对黑色素瘤基因环境癌症风险的认识
  • 批准号:
    6681775
  • 财政年份:
    2003
  • 资助金额:
    $ 13.43万
  • 项目类别:
Perception of Gene-Environment Cancer Risks in Melanoma
对黑色素瘤基因环境癌症风险的认识
  • 批准号:
    7120526
  • 财政年份:
    2003
  • 资助金额:
    $ 13.43万
  • 项目类别:

相似海外基金

Clinical Research and Academic Success in Obstetrics & Gynecology
产科临床研究和学术成就
  • 批准号:
    10828252
  • 财政年份:
    2023
  • 资助金额:
    $ 13.43万
  • 项目类别:
Clinical Research Support Core
临床研究支持核心
  • 批准号:
    10682166
  • 财政年份:
    2023
  • 资助金额:
    $ 13.43万
  • 项目类别:
User-centered approach to the development of a parent toolkit to improve willingness to participate in pediatric clinical research
以用户为中心的方法开发家长工具包,以提高参与儿科临床研究的意愿
  • 批准号:
    10663456
  • 财政年份:
    2023
  • 资助金额:
    $ 13.43万
  • 项目类别:
An Integrated Neurochemical/Electrophysiological Recording and Neuromodulation System for Basic and Clinical Research
用于基础和临床研究的集成神经化学/电生理记录和神经调节系统
  • 批准号:
    10477708
  • 财政年份:
    2022
  • 资助金额:
    $ 13.43万
  • 项目类别:
Imperial County Clinical Research Network for Health Equity
帝国县健康公平临床研究网络
  • 批准号:
    10709891
  • 财政年份:
    2022
  • 资助金额:
    $ 13.43万
  • 项目类别:
Rare Disease Clinical Research Training Program
罕见病临床研究培训计划
  • 批准号:
    10489961
  • 财政年份:
    2022
  • 资助金额:
    $ 13.43万
  • 项目类别:
Imperial County Clinical Research Network for Health Equity
帝国县健康公平临床研究网络
  • 批准号:
    10631785
  • 财政年份:
    2022
  • 资助金额:
    $ 13.43万
  • 项目类别:
Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center
城市环境中的儿童哮喘临床研究网络 - 领导中心
  • 批准号:
    10209602
  • 财政年份:
    2021
  • 资助金额:
    $ 13.43万
  • 项目类别:
Conference Grant (R-13) Covering Three Years of Cochlear Implant Clinical Research Symposia to be held in 2021, 2022 and 2023
会议拨款 (R-13),涵盖将于 2021 年、2022 年和 2023 年举行的为期三年的人工耳蜗临床研究研讨会
  • 批准号:
    10230826
  • 财政年份:
    2021
  • 资助金额:
    $ 13.43万
  • 项目类别:
Conference Grant (R-13) Covering Three Years of Cochlear Implant Clinical Research Symposia to be held in 2021, 2022 and 2023
会议拨款 (R-13),涵盖将于 2021 年、2022 年和 2023 年举行的为期三年的人工耳蜗临床研究研讨会
  • 批准号:
    10394973
  • 财政年份:
    2021
  • 资助金额:
    $ 13.43万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了