Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)

德克萨斯州BioMed In-TRAC总体摘要 德克萨斯州生物医学研究中心跨学科NexGen结核病研究促进中心(IN-TRAC) 德克萨斯生物医学研究所将吸引下一代多样化的研究人员参与结核病(TB)的研究 领域，并将他们培养成具有多学科技能和现实世界经验的独立研究人员 临床结核病。IN-TRAC的产品将是选择在一些最具挑战性的领域工作的研究人员 和相关的结核病翻译问题，并在跨学科和框架内工作 高度协作的研究。这将通过6个相互关联的核心来实现。管理核心： TRAC内管理和监督的中央中心，负责行政和科学 领导力；协调核心、研究人员和NIH/NIAID计划工作人员之间的沟通 提供一个组织结构，以优化多学科协作和 在核心和不同的“核心预算资源调拨目标”参与者之间开展了一项研究。发展核心：监督所有职业 发展规划和课程，量身定制研究和临床经验，包括实习生和 向每一名内部TRAC项目参与者发放外部奖学金，以及管理内部TRAC项目试点赠款计划。 生物安全和生物遏制核心：将所需的生物安全培训扩展到个性化课程 包括理论和实际操作的生物遏制培训，了解机械和监管 BSL3/ABSL3的要求，如何开发生物安全协议的指导，以及如何应对风险 从生物安全官员的角度进行评估。研究成像核心：提供理论和 单细胞成像实践培训(共焦显微镜、细胞术、活细胞成像、单细胞RNAseq) 通过在小鼠(IVIS)和非人灵长类动物(NHP)(PET/CT)中进行全身成像 配备BSL3/ABSL3设施。动物模型核心：实施培训计划以引入All-TRAC 参与者要按照监管要求处理啮齿动物和NHP，如何制定一个健壮的 实验协议，如何编写IACUC协议，以及动手操作动物和实验 程序。临床研究和患者护理核心：向TRAC参与者介绍结核病患者护理 美国唯一一家独立的结核病医院(德克萨斯传染病中心)，管理着一些 全国最具挑战性的结核病病例。与此合作将是美国的一次临床研究体验- 墨西哥边境，在服务不足和资源不足的社区体验结核病研究。

TEXAS BIOMED IN-TRAC OVERALL ABSTRACT The Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) at Texas Biomedical Research Institute (Texas Biomed) will attract the next generation of diverse researchers to the tuberculosis (TB) research field, and develop them into independent researchers with multi-disciplinary skills and real-world experience of clinical TB. The product of IN-TRAC will be researchers that choose to work on some of the most challenging and relevant translational problems in TB, and that work across academic disciplines and within a framework of highly collaborative research. This will be achieved through 6 interrelated Cores. Administrative Core: The central hub of IN-TRAC management and oversight, with responsibility for administrative and scientific leadership; coordinating communication between Cores, researchers and NIH/NIAID Program staff and providing an organizational structure to optimize multidisciplinary collaborations and interactions between the Cores and among a diverse cohort of IN-TRAC participants. Development Core: Oversight of all career development programming and courses, tailoring the research and clinical experiences, both intern and externships, to each individual IN-TRAC participant, and management of the IN-TRAC pilot grant program. Biosafety & Biocontainment Core: Extending the required biosafety training to a personalized curriculum including theoretical and hands-on biocontainment training, understanding the mechanical and regulatory requirements of a BSL3/ABSL3, coaching on how to develop biosafety protocols, and working through risk assessments from the perspective of a Biosafety Officer. Research Imaging Core: Providing theoretical and hands-on training from single cell imaging (confocal microscopy, cytometry, live cell imaging, single cell RNAseq) through to whole body imaging in mice (IVIS) and Non-human primates (NHP) (PET/CT) within large, fully outfitted BSL3/ABSL3 facilities. Animal Model Core: Implementing a training program to introduce all IN-TRAC participants to the regulatory requirements for working with rodents and NHPs, how to develop a robust experimental protocol, how to write an IACUC protocol, and hands-on animal handling and experimental procedures. Clinical Research & Patient Care Core: Introducing IN-TRAC participants to TB patient care at the only free-standing TB hospital in the US (Texas Center of Infectious Diseases) that manages some of the most challenging cases of TB nationally. Partnering with this will be a clinical research experience at the US- Mexico border, to experience TB studies in under-served and under-resourced communities.