CELLULAR AND MOLECULAR IMAGING CORE

细胞和分子成像核心，起源于1977年，促进了杰出的和 西雅图地区糖尿病研究中心分支机构的创新研究 在(免疫)组织化学、显微成像和 图像分析。在下一个资助周期中，CMIC将继续推动这些研究人员的研究 提供：(1)糖尿病相关技术和科学方面的专家支持，包括研究咨询 设计、使用适当的控制措施并解释结果；(2)严格的量化评估 免疫组织化学和组织形态变化；(3)经济高效地获取最新技术 成像仪器；(4)对附属机构、其受训人员和具有以下技能的人员进行实践和教学培训 常规和高度专业化的形态、组织化学和成像技术；以及(5)获得临床 和比较病理学家协助进行实验和/或临床前研究。通过所有这一切 服务、核心领导层和员工分享他们在处理糖尿病相关组织和 解释与疾病相关的细胞成分/形态的变化。细胞与分子成像 CORE非常重视确保研究的严谨性和重复性的高标准 在核心地区进行。这包括但不限于试剂的严格质量控制、专家评审 确保适当和充分地使用积极和消极控制措施。核心优惠 为自动化、常规、共聚焦和超免疫组织化学提供多种最先进的服务 分辨率显微镜、激光捕获显微解剖和自动化/人工智能图像分析。通过实现这些 目标，细胞和分子成像核心将继续支持对附属公司的科学调查 研究人员将使用核心来加深我们对糖尿病和相关疾病的了解。

The Cellular and Molecular Imaging Core, which had its origin in 1977, facilitates the outstanding and innovative research of Diabetes Research Center affiliates in the Seattle area by keeping pace with and pioneering new methodological and technical advances in (immuno)histochemistry, microscopic imaging and image analysis. In the next funding cycle the CMIC will continue to promote the research of these investigators by providing: (1) Expert diabetes-related technical and scientific support, including consultation for study design, use of appropriate controls, and interpretation of results; (2) Rigorous quantitative assessment of immunohistochemistry and morphological changes in tissues; (3) Cost-effective access to state-of-the-art imaging instrumentation; (4) Hands-on and didactic training to affiliates, their trainees, and personnel with routine and highly specialized morphological, histochemical, and imaging techniques; and (5) Access to clinical and comparative pathologists to assist with experimental and/or preclinical studies. Through all of these services, Core leadership and staff share their deep expertise in working with diabetes-relevant tissues and in interpreting disease-related changes in cellular composition/morphology. The Cellular and Molecular Imaging Core places a great deal of emphasis on ensuring high standards of rigor and reproducibility for studies undertaken in the Core. This includes, but is not limited to, rigorous quality control for reagents, expert review of protocols and ensuring appropriate and adequate use of positive and negative controls. The Core offers multiple state-of-the-art services for automated immunohistochemistry, conventional, confocal and super- resolution microscopy, laser capture microdissection and automated/AI image analysis. By achieving these goals, the Cellular and Molecular Imaging Core will continue to support the scientific investigation of affiliate investigators who will use the Core to further our understanding of diabetes and related disorders.