Stanford Precision Health for Ethnic and Racial Equity (SPHERE) Transdisciplinary Collaborative Center

 描述（由申请人提供）：虽然基因本身不是理解种族和民族健康差异的充分单一基础，但差异环境（包括治疗）与不同亚组中差异基因互补相互作用的潜力确实构成了研究健康差异的肥沃背景。在斯坦福大学，我们在形成协调，可持续和意义深远的研究所需的三个关键学术要素方面具有突出的优势，以实践合作，以解决种族和民族健康差异，重点是：1）在遗传标记的实验室评估及其与疾病风险和治疗相关性的关系方面的广泛经验，2）社会差异研究人员，跨越流行病学，进化生物学，卫生服务研究和经济学，以及3）新颖和杰出的分析和高性能计算能力，最近在我们的生物医学数据科学系巩固。在我们新的斯坦福大学人口健康科学中心的主持下，我们最近加倍了对社区影响的投资。正是在这种背景下，我们提出了U54申请的以下总体目标：具体目标1：将三个主要科学领域聚集在一起，形成新的工作关系，以实现三个拟议研究项目的目标，同时发展成为一个综合和可持续的科学“团队”，能够承担我们的联盟合作伙伴和全国各地的姐妹中心提出的新试点项目。同时扩大我们自己的精准健康研究组合，重点关注随着时间的推移健康差异。具体目标二：支持联盟和实施核心，发展和扩大与我们最初的研究合作伙伴的关系，以促进社区中关键的双向研究关系，从三个拟议的项目开始，并成熟为广泛的，可持续的伙伴关系，以确保随着研究的推进，进一步纳入受不利影响的人群。具体目标3：在不同种族和民族群体中“翻译”遗传和生物信息方面积累广泛经验，以优化此类精确健康方法的应用，从而在此类方法最相关的地方减少民族和种族差异。

 DESCRIPTION (provided by applicant): While genes per se are not an adequate singular foundation for understanding racial and ethnic health disparities, the potential of differential environments-including treatments-interacting with a differential complement of genes in different subgroups does constitute a fertile context for the study of health disparities. At Stanford, we have in place outstanding strengths in the three critical academic elements requisite to form a coordinated, sustainable, and far-reaching research to practice collaboration to address racial and ethnic health disparities with this focus: 1) Extensive experience both with laboratory assessment of genetic markers and their relationships to both disease risk and treatment relevance, 2) Social disparities researchers, spanning epidemiology, evolutionary biology, health services research and economics, and 3) Novel and outstanding analytic and high-performance computing capabilities, recently consolidated in our Department of Biomedical Data Science. Under the auspices of our new Stanford Center for Population Health Sciences, we have recently redoubled our investments in Community Impact. It is in this context that we propose the following overarching aims for this U54 application: Specific Aim 1: Draw together the three principal scientific domains into new working relationships to achieve the aims of each of the three proposed research projects while evolving into an integrated and sustainable science "team" able to take on novel pilot projects proposed by our consortium partners, and sister Centers around the country, while expanding our own portfolio of precision health research focusing on health disparities over time. Specific Aim 2: Availing the Consortium and Implementation Cores, develop and expand relationships with our initial research partners to facilitate critical bidirectional research relationships in the community, starting with the three proposed projects and maturing into a broad, sustainable nexus of partnerships to ensure inclusion of further adversely impacted populations as research goes forward. Specific Aim 3: Develop broad experience with "translation" of genetic and biologic information within different racial and ethnic populations to optimize the application of such precision health approaches to reduce ethnic and racial disparities where such approaches are most relevant.