Healthy transitions from mid-life to early older age: biomedical follow-up of 1958 Birth Cohort Study members at age 60

7.项目总结/摘要 在过去的世纪里，人类预期寿命的增长是最大的增长之一， 公共卫生医学的成就。然而，它也对卫生和 社会保健，特别是慢性病和相关的老龄化状况， 认知障碍和虚弱。了解这些老龄化结果的发生和决定因素 已成为具有重大政策影响的全球研究重点。了几项研究 在美国（HRS，MIDUS）的中老年人群中建立，有能力提供更多- 需要深入了解这些问题。然而，最近的情况表明， 在生命过程中，衰老状态开始的时间比最初想象的要早得多，在某些情况下，早在出生时， 先入为主正是在这种以生命历程为导向的研究中，美国令人惊讶地被剥夺了。1958年英国 英国的出生队列研究是这类研究中规模最大的长期研究。与研究成员 年届六十，当老化问题开始频繁出现时，我们会进行一项 详细的表型和基因型调查，涵盖一系列领域，包括生物，心理， 社会经济和行为特征。独特的是，这些新数据将使我们能够回答一系列 公共卫生重要性的重要研究问题，从确定政策修改， 中年人的行为和生物机制，成功地扭转了早期生活暴露的影响 和逆境对老龄化结果的影响，通过研究早期生活教育的长期影响， 对老年人的社会、健康和老龄化结果进行干预，开展一系列跨国活动， 跨队列比较，使我们能够突出这些过程在代际之间发生的变化，或 国家间这些数据将很快被真正的人口科学家所利用。 收集，因此为科学界提供了无与伦比的资源，以调查一系列政策- 有关问题

7. Project Summary/Abstract The unrivalled increase in human life expectancy over the last century has been one of the greatest achievements of public health medicine. However, it also poses new and unique challenges in health and social care, in particular the increased burden of chronic diseases and associated ageing states, including cognitive impairment and frailty. Understanding the occurrence and determinants of these ageing outcomes has become a global research priority with considerable policy implications. Several studies have been established in middle- and older-aged populations in the US (HRS, MIDUS) with the capacity to offer much- needed insights into these issues. However, it has recently become evident that the processes that underlie ageing states begin much sooner in the life course than originally thought, in some cases as early as birth or preconception. It is in such life course-orientated studies that the USA is surprisingly bereft. The 1958 British Birth Cohort Study in the UK is the largest long-running study of this genre. With the study members approaching 60 years of age, when problems of ageing begin to emerge with frequency, we will carry out a detailed phenotypic and genotypic survey which covers an array of areas including biological, psychological, socioeconomic and behavioural characteristics. Uniquely, these new data will allow us to answer a series of important research questions of public health importance, ranging from identifying the policy-modifiable behaviours and biological mechanisms in mid-life that successfully reverse the effects of earlier life exposures and adversities on ageing outcomes, through to examining the long term influence of early life educational interventions on social, health, and ageing outcomes in older age, on to running a series of cross-country, and cross-cohort comparisons, to enable us to highlight where such processes are changing across generations, or between countries. These data will become publically available to bone fide population scientists soon after collection, so providing an unrivalled resource for the scientific community to investigate a range of policy- relevant issues.