Core C: Imaging, Molecular Biology & Nanomaterial

核心C：成像，分子生物学和纳米医学核心（IMBN） 7.项目总结/摘要 成像，分子生物学和纳米医学核心（IMBN）的任务是1）提供仪器， 技术和专业知识服务，对骨骼健康和修复感兴趣的研究人员，2）保持国家的， 支持肌肉骨骼科学家的动物成像、分子生物学和纳米医学艺术实验室 和临床医生开发和完成高质量的研究项目，和3）成为一个财政 一个独立的中心，可以继续蓬勃发展，一旦第三阶段结束。本核心提供的服务， 自第一阶段和第二阶段开始以来，提高了骨骼的生产力和研究能力， 系统调查员，并在获得校外资金方面提供了竞争优势。RIH有一个 在扩大其研究基础设施方面进行了重大投资，如整个中心所详细说明的那样 本申请的组织和管理计划。这引起并维持了人们对以下问题的极大兴趣： 利用核心服务，以及RIH和骨科的重大担保共同出资 在第三阶段供资期间和之后，将允许IMBN核心的可持续性。我们将 提供以下核心服务：1）提供复杂的，最先进的翻译仪器 研究，重点是动物模型和人体组织样本，以COBRE的不同项目，2） 在分子、细胞、组织和整个生物体水平提供技术支持和专家咨询， 罗得岛生物医学界-包括生物学家，临床医生和工程师，和3）提供切割- 边缘纳米材料和纳米技术，以支持研究人员将基础研究转化为临床 应用.

Core C: Imaging, Molecular Biology & Nanomedicine Core (IMBN) 7. Project Summary/Abstract The missions of the Imaging, Molecular Biology & Nanomedicine Core (IMBN) are 1) to provide instrument, technical, and expertise services to researchers interested in skeletal health and repair, 2) to maintain state-of- art laboratories in animal imaging, molecular biology and nanomedicine supporting musculoskeletal scientists and clinicians to develop and accomplish high-quality research projects, and 3) to become a financially independent center that can continue to thrive once Phase III comes to an end. Services provided by this Core, since inception during phase I and II, have enhanced the productivity and research capabilities of skeletal system investigators and have provided a competitive advantage in garnering extramural funding. RIH has a made a significant investment in expanding its research infrastructure, as detailed in the overall center organization and management plan of this application. This has generated and sustained enormous interest in utilization of Core services that, together with significant guaranteed co-founding by RIH and Orthopedic Department, will allow sustainability of the IMBN Core during and after the Phase III funding period. We will provide the Core services as follows: 1) Provide sophisticated, state-of-the-art instrumentation in translational research, with emphasis on animal models and human tissue samples, to different projects in the COBRE, 2) Provide technical support and expert consultation in the molecular, cell, tissue, and whole organism levels to Rhode Island biomedical community - including biologists, clinicians and engineers, and 3) Provide cutting- edge nanomaterial and nanotechnology to support investigators translating basic research into clinical applications.