Biological Imaging Core

生物成像--综述 生物成像(BI)模块提供最先进的设备和资源 生物组织的组织学分析和分析成像，用于训练视力研究 研究人员使用这些技术，并促进新的合作研究 既有老牌的也有新兴的调查人员。具体目标是：1)提供最先进的 分析成像和组织学的技术和服务是无法实现的 单独的实验室和高通量常规组织处理2)以提供 对新的研究人员和工作人员进行关于显微镜、成像软件方面的先进技术的培训 以及其他模块设备，包括组织学组织和数字图形的准备 制作，3)促进早期调查人员的研究并促进互动和 在整个大学范围内，不同视野的研究社区之间的合作。BI模块是 在上一个赠款周期中广泛使用，对促进创新愿景至关重要 研究，包括测试新疗法的有效性，开发和验证病毒表达 基因治疗项目的载体，研究疾病期间受体-配体的相互作用， 确定生物标记物，并验证蛋白质组学/代谢组学数据，如下所述。这个 BI模块用于生成在许多出版物中报告的数据，并包括 在新的奖励金中。本模块将继续提供必要的翻译资源 为麦克奈特视力研究中心(MVRC)的研究人员提供基础科学研究。

Biological Imaging - Summary The Biological Imaging (BI) Module provides state-of-the-art equipment and resources for histological analysis and analytical imaging of biological tissues, for training vision research investigators in the use of these technologies, and to promote new collaborative studies among established and emerging investigators. Specific Aims are: 1) To provide state-of-the-art technology and services for Analytical Imaging and Histology which are beyond reach of individual laboratories, and high-throughput conventional tissue processing 2) To provide training for new investigators and staff on advanced techniques in microscopy, imaging software and other module equipment including preparation of histological tissue and digital graphics production, 3) To promote research of early stage investigators and foster interaction and collaboration among a university-wide, diverse vision research community. The BI module was extensively used in the last grant cycle and was essential for promoting innovative vision research, including testing efficacy of novel therapies, developing and validating viral expression vectors for gene therapy projects, investigating receptor-ligand interactions during disease, identifying biomarkers, and validating proteomics/metabolomics data, as described below. The BI module was used to generate data that was reported in numerous publications and included in new grant awards. This module will continue to provide an essential resource for translational and basic science research for investigators of the McKnight Vision Research center (MVRC).