TB-RICC 3.0

TB-RICC 3.0旨在支持区域前瞻性观测研究 结核病(报告)联盟将产生最高质量的观察性和 结核病、结核病-艾滋病毒和结核病-新冠肺炎的干预研究。要做到这一点 目标，TB-RICC 3.0将：i)与报告国家/地区网络数据中心和 确保《共同议定书》的共同数据元素(CDE)和 可通过全球数据模板进行标本跟踪；二)组织和/或 加强选定地点参与诊断研究和临床试验；以及iii)支持 报告国家--确保结核病诊断实验室进一步发展的网络 RICC 3.0专业实验室和生物库。TB-RICC3.0的目标是：协调 中心结构和职能：成立领导小组和执行委员会；确保 对内对外有效沟通；建立数据枢纽，提供无缝数据 从收集到分析的管理；建立科学工作组；科学评论 委员会和行政核心；促进向潜在资助者和 合伙人。数据协调：开发数据中心，与国家级数据中心协作 利用红帽协调平台和其他工具促进多区域数据工作流程； 研究：催化结核病、结核病/艾滋病毒和结核病/新冠肺炎研究报告 网络，并与外部伙伴合作；优先研究结核病密切接触者以评估生物标记物 预测三个“组学”平台和三大洲的结核病进展情况；能力 建设：为结核病研究组成部分的能力建设开发模块化远程课程； 指导早期调查员(ESI)开发。TB-RICC 3.0将提供高影响力 推进结核病科学和结核病控制的创新研究

TB-RICC 3.0 is designed to support the Regional Prospective Observational Research Tuberculosis (RePORT) Consortium to produce the highest quality observational and interventional research on tuberculosis (TB), TB-HIV, and TB-COVID-19. To accomplish this goal, TB-RICC 3.0 will: i) collaborate with RePORT Country-Network Data Centers and Biorepositories to ensure that common data elements (CDE) of the Common Protocol and Specimen Tracking are accessible through the Global Data Template; ii) organize and/or strengthen select sites to participate in diagnostic studies and clinical trials; and iii) support the RePORT Country-Networks to ensure further development of TB diagnostic laboratories, TB- RICC 3.0 specialized laboratories, and biorepositories. Aims of TB-RICC 3.0 are: Coordinating Center Structure and Function: develop a Leadership Group and Executive Committee; assure effective communication internally and externally; establish a Data Hub to provide seamless data management from collection to analysis; establish Scientific Working Groups; a Scientific Review Committee and an Administrative Core; facilitate grant submissions to potential funders and partners. Data Harmonization: Develop a data hub to collaborate with country-level data centers to facilitate multiregional data workflow using the REDCap Harmonist platform and other tools; Research: catalyze TB, TB/HIV and TB/COVID-19 research within and across RePORT Country Networks, and with external partners; prioritize study of TB close contacts to evaluate biomarkers predictive of progression to TB across three “omics” platforms and three continents; Capacity Building: develop modular remote courses for capacity building in the components of TB research; Mentor early-stage investigator (ESI) development. TB-RICC 3.0 will deliver high-impact innovative research to advance TB Science and TB Control