CELLULAR AND MOLECULAR GEROSCIENCE CoBRE

Sonntag，William E.，博士 P20GM125528 摘要 在理解衰老的分子和细胞机制方面已经取得了令人印象深刻的进展， 包括发现延缓衰老和增加健康寿命的方法。重要的是这些 干预措施还可减少或预防与年龄有关的疾病。这些结果提高了多个 人类疾病的产生有一个共同的原因-老化。这个CoBRE第一阶段的前提是， 衰老的机制和与年龄相关的疾病的机制有着共同的细胞和分子机制， 健康和寿命的基础过程。这一概念的一个重要推论是， 年龄相关疾病的临床研究必须包括对细胞/分子变化的理解， 以充分开发与年龄有关的疾病的治疗方法。在这里，我们提出一个 多学科、跨部门和跨机构的CoBRE计划，重点关注蜂窝和 分子老年科学老年科学是一个相对较新的跨学科科学领域， 随着年龄的增长，细胞和分子事件大大增加了疾病的风险， 因此，疾病呈指数增长。我们的计划有特殊的机构支持。 该计划是高度创新的，因为它结合了有前途的初级调查员（PJIs）的指导， 目前正在研究衰老机制的杰出科学专家和研究年龄的教师， 以一种将提高正在进行的疾病相关研究的数量和质量的方式， in the context上下文of the aging老化organism有机体.这些目标将通过指导PJIs来实现，PJIs 在OUHSC有教师任命;招聘高级调查员到OUHSC校园;和发展 支持研究计划的必要基础设施。该计划的具体目标是：1。 发展和扩大机构生物医学研究在老年科学通过指导PJIs的高度 经验丰富敬业的高级调查员2.加强对扩大老年科学至关重要的基础设施 在俄克拉荷马州做研究。3.促进CoBRE调查人员之间的学院和合作关系， 其他科学家。4.建立里程碑和期望，以确保计划的成功及其 参与者这个补充的目的是推进我们的研究到单细胞transciptomics使用 Chromium和Chromium Connect技术。

Sonntag, William E., PhD P20GM125528 ABSTRACT There have been impressive advances in understanding the molecular and cellular mechanisms of aging, including the discovery of manipulations that delay aging and increase healthspan. Importantly, these interventions also reduce or prevent age-related diseases. These outcomes raise the possibility that multiple human diseases arise from a common cause – aging. The premise of this CoBRE Phase 1 is that the mechanisms of aging and the mechanisms of age-related diseases share common cellular and molecular processes that underlie healthspan and lifespan. An important corollary to this concept is that pre-clinical and clinical research on age-related diseases must incorporate an understanding of the cellular/molecular changes that occur with age in order to adequately develop treatments for age-related diseases. Here, we propose a multidisciplinary, inter-departmental, and inter-institutional CoBRE program focused on Cellular and Molecular Geroscience. Geroscience is a relatively new, interdisciplinary scientific field that addresses the cellular and molecular events that dramatically increase the risk for disease with age, create a ‘permissive milieu’ and, as a result, disease increases exponentially. Our program has exceptional institutional support. The program is highly innovative in that it combines mentoring of promising junior investigators (PJIs) by outstanding scientific experts who are currently studying mechanisms of aging and by faculty investigating age- related disease in a manner that will increase both the quantity and quality of on-going disease-related research in the context of the aging organism. These goals will be accomplished through the mentoring of PJIs, who have faculty appointments at OUHSC; recruiting senior investigators to the OUHSC campus; and developing the necessary infrastructure for support of the research program. The specific aims for the program are: 1. Develop and expand institutional biomedical research in Geroscience through the mentoring of PJIs by highly experienced, dedicated senior investigators. 2. Enhance the infrastructure critical for expanding Geroscience research in Oklahoma. 3. Foster collegial and collaborative relationships between CoBRE investigators and other scientists. 4. Establish milestones and expectations that ensure the success of the program and its participants. This supplement is designed to advance our research into single cell transciptomics using Chromium and Chromium Connect technology.