An Analysis of Psychosocial Risk and Protective Factors: Accelerated Cognitive Aging and Mild Traumatic Brain Injury (MTBI) Among Retired NFL & Former NCAA Football Players

项目摘要/摘要： 罗伯特·W·特纳二世是乔治大学临床研究和领导力系助理教授 华盛顿大学(GW)和杜克大学健康与社会中心的研究科学家。 目前的提议是对他指导的研究科学家进行为期一年的行政补充 NIA颁发的发展奖(1K01AG054762-01A1)，以表彰解决HIS中差距的培训和支持 与轻度创伤性脑损伤相关的阿尔茨海默病(AD)的生物行为因素的知识 (MTBI)和加速认知老化。由于新冠肺炎大流行相关的不可预见的问题， 特纳博士经历了他的科学和职业发展计划的重大中断。在……里面 与他的导师合作，他制定了一项全面的培训和研究计划，这两个计划都将填补 这些知识差距，并为他的独立研究生涯做好准备。他的K01的首要目标是 在心理社会和神经认知因素的多个测量之间的相互关系方面获得专业知识 与认知老化加速有关的阿尔茨海默病。为了实现这一目标，他提议 继续致力于三项职业发展活动和三项研究目标，将指导与 在调查研究技术方面有经验的学者；与导师进行一对一的个性化培训；最后， 自始至终进行“概念验证研究”。这三个研究目标将使他能够将 并应用通过拟议的培训活动获得的知识，创建更有力的 可能影响mTBI在男性中的长期后果的心理社会保护和风险因素 以前是有可能的。本项目使用的办法将解决：a)男性在预测影响方面的脆弱性 心理社会因素对认知老化加速的影响以及b)对男子气概的理解是如何发展的。 以及在与疼痛、损伤和大脑健康相关的组内。通过实现这些目标，他将考验重要的 假说，并为描述痴呆的相关过程做出了实质性的循证贡献 MTBI导致的认知加速衰老。这项提案与公共卫生相关，因为它将探讨 解决脑震荡患者的功能、认知和心理社会脆弱性的创新方法，以及 可能最终降低慢性创伤性脑病(CTE)和阿尔茨海默病(AD)的风险 脑震荡造成的。它还将为R系列拨款提案提供信息，以研究与mTBI相关的认知加速老化 特纳博士计划在该项目的最后一年提交。

Project Summary/Abstract: Robert W. Turner II is an Assistant Professor in the Department of Clinical Research and Leadership at George Washington University (GW), and a Research Scientist in the Center on Health and Society at Duke University. The current proposal is for a one-year administrative supplement to his Mentored Research Scientist Development Award (1K01AG054762-01A1) from NIA for training and support that address gaps in his knowledge of biobehavioral factors underlying Alzheimer’s Disease (AD) related to mild traumatic brain injury (mTBI) and accelerated cognitive aging. As a result of unforeseen issues related to the COVID-19 pandemic, Dr. Turner experienced significant disruption to his scientific and career development plan. In collaboration with his mentors he has developed a comprehensive training and research plan that will both fill in these knowledge gaps and prepare him for an independent research career. The overarching goal of his K01 is to gain expertise on the interrelationships between multiple measures of psychosocial and neurocognitive factors associated with AD dementia related to accelerated cognitive aging. To accomplish this goal, he proposes to continue working on three career development activities and three research aims that combines instruction with established scholars in survey research techniques; one-to-one individualized trainings with mentors; and finally, conducting of a “proof of concept study” from start to finish. The three research aims will enable him to integrate and apply knowledge gained through the proposed training activities by creating a more robust portrait of psychosocial protective and risk factors that may impact the long-term consequences of mTBI among men than previously possible. The approach used in this project will address; a) male vulnerabilities in predicting the impact of psychosocial factors on accelerated cognitive aging and b) how understandings of masculinity develop across and within groups in relationship to pain, injury, and brain health. By completing these aims, he will test important hypotheses and make substantial evidence-based contributions to describing the process of dementia related cognitive accelerated aging resulting from mTBI. This proposal is relevant to public health because it will explore innovative approaches to address functional, cognitive, and psychosocial vulnerabilities in concussed men, and may ultimately reduce the risk of Chronic Traumatic Encephalopathy (CTE), and Alzheimer’s disease resulting from concussions. It will also inform an R-series grant proposal to study mTBI related accelerated cognitive aging and brain imaging that Dr. Turner plans to submit in the final year of the project.