Promoting health by understanding the dynamic interplay between internalizing symptoms and substance use among Latinx youth in rural and small-town communities in the United States

本申请是对拉丁美洲农村地区健康项目（R 01 DA 048827）的补充，适用于 预防科学范式，以检查物质使用的病因学和相关的个人，家庭， 拉丁裔农村青少年和年轻人的社区风险和保护因素。该补充将 将母项目扩展到心理健康领域，并研究 农村青少年和青年期的抑郁、焦虑和物质使用情况 拉丁裔青年，近年来迅速增长的服务不足和边缘化人口。很长的- 候选人Griselda Martinez女士的任期职业目标是成为一名独立调查员， 整合了药物滥用的发展模式和促进健康公平的因素， 人口本补充的主要目的是了解发展之间的联系 使用文化发展透镜宣传潜在的预防措施， 干预目标和时机。这些目标将通过以下两个具体目标实现： 研究抑郁症状和物质使用之间的相互和纵向联系， 青春期的过程，以及农村和农村之间在这些联系方面存在差异的程度。 来自移民的拉丁裔青年与美国-出生（第三代）家庭和第三代农村拉丁青年之间， 非拉丁裔白人性别差异、外化生殖学以及多种生殖器疾病的风险和保护因素 域将被测试。例如，家庭层面的因素，包括家庭纽带和家庭冲突， 将研究文化适应的变化。(2)检查内在化精神病学 （抑郁和焦虑）和物质使用在年轻的成年人，并确定在多大程度上有 感兴趣的比较组中的差异。缺乏医疗保健等系统性障碍将 也要检查。候选人将在卡特琳娜博士的监督下进行研究 Guttmannova博士和父母资助的Co-Is团队跨越三个多学科站点， 在酒精和健康差异研究之外的物质滥用发展模型中， 熟练掌握纵向方法，并为未来的独立研究资金奠定基础。 培训活动包括指导会议、高级统计研讨会、与主要统计机构的磋商、 物质滥用和相关健康风险行为的病因学研究人员，以及赠款写作。这 补充将使候选人能够将时间用于拟议的活动， 独立作为一个调查员，这将从而增加人数不足的研究人员 在药物滥用研究领域开展研究。

This application is a supplement to the Latinx Health in Rural Areas project (R01DA048827) that applies prevention science paradigm to examine etiology of substance use and related individual, family, and community risk and protective factors among rural Latinx adolescents and young adults. The supplement will extend the parent project into the area of mental health and examine the dynamic interplay between depression and anxiety and substance use over the course of adolescence and young adulthood among rural Latinx youth, an underserved and marginalized population that has grown rapidly in recent years. The long- term career goal of the candidate, Ms. Griselda Martinez, is to become an independent investigator that integrates developmental models of substance misuse and factors that promote health equity in this population. The primary objective of this supplement is to understand the developmental links between substance use and mental health using a cultural-developmental lens to inform potential prevention and intervention targets and their timing. These objectives will be accomplished in two specific aims that: (1) examine the reciprocal and longitudinal associations between depressive symptoms and substance use over the course of adolescence, and the extent to which there are differences in these associations between rural Latinx youth from immigrant vs. U.S.-born (3rd gen) families and between 3rd generation rural Latinx youth and non-Latinx Whites. Sex differences, externalizing symptomatology, and risk and protective factors from multiple domains will be tested. For instance, family-level factors, including family bonding and family conflict that may change with acculturation will be examined. (2) Examine links between internalizing symptomatology (depression and anxiety) and substance use in young adulthood and determine the extent to which there are differences in the comparison groups of interest. Systemic barriers such as lack of access to healthcare will also be examined. The candidate will conduct the research under the supervision of Dr. Katarina Guttmannova, PhD, and the parent grant’s team of Co-Is across three multidisciplinary sites to gain expertise in developmental models of substance misuse beyond alcohol and health disparities research, deepen her proficiency with longitudinal methodologies, and lay groundwork for future independent research funding. Training activities include mentorship meetings, advanced statistics seminars, consultation with leading researchers on etiology of substance misuse and related health risk behaviors, and grant writing. This supplement will allow the candidate to dedicate her time to the proposed activities aimed at establishing independence as an investigator, which will thereby increase the number of underrepresented research faculty conducting research in the field of drug abuse research.