Predicting Alcohol Use and Alcohol Use Disorder Symptoms from Subjective Responses to Alcohol in a Laboratory Social Setting

项目总结/摘要 建议的项目是一个新的和早期的研究员为R 01（资助）的新提交的文件 机会公告PAR-16-260）。 绝大多数的酒精使用发生在社会环境中，但几乎所有的人类实验 研究人员曾将酒精单独给予个体。这一研究背景抑制了关于 酒精刺激，增加积极的影响，减少消极的影响，这使得它不可能 测量了许多主观上令人愉快的酒精的社会影响，这些影响增加了酒精的风险 使用障碍（AUD）（例如，增加社交能力，减少社交焦虑）。值得注意的是，到目前为止，实验室 对酒精的主观反应（SRA）仅占4%至6%， 未来AUD症状的差异。这项拟议中的研究将是第一个检验酒精影响的研究 在社会群体中的一些领域假设调解酒精使用，并测试是否 这些反应可以更好地预测AUD症状的发展。此外，这项研究将是第一个 使用生态瞬时评估（EMA）检查中间现实世界的饮酒体验 方法，以评估基于实验室的SRA如何转化为实验室外的风险过程。 384名重度饮酒者（50%为女性;年龄21-25岁）将被组装成128个三- 个人团体。每组的所有成员将在36分钟内饮用中等剂量的酒精（男性： 0.82 g/kg;雌性：0.74 g/kg）或安慰剂饮料; SRA和社会奖励（例如，社会联系）将是 使用跨多个响应系统的广泛测量进行评估（例如，自我报告， 微笑和言语模式的观察测量）。饮酒行为，SRA，和急性酒精- 在随后的三次EMA爆发期间，将评估日常生活中的相关问题， 将在基线和12个月随访时进行评估。 我们预测，饮酒的参与者会经历更多的刺激/积极影响， 渴望和社会奖励（例如，社会联系）和更少镇静、负面影响和社会不适 在血液酒精曲线的上升段，通过多个反应系统测量， 喝安慰剂此外，我们预测，这些基于实验室的SRA和社会奖励指数将 具有临床意义，也就是说，我们期望它们能够预测SRA，重度饮酒， 在12个月的随访中，日常生活中的急性酒精相关问题更多，AUD症状更多。 最后，我们预测日常生活中的SRA将介导实验室SRA与AUD之间的联系 症状我们还将测试有AUD风险的个体（例如，由于性格，遗传学） 在实验室和日常生活中对酒精的影响特别敏感， 随着时间的推移，酒精使用和更多AUD症状的发展。这项工作，通过开发一个 实验室社交饮酒范式预测现实世界的酒精反应和AUD风险，可以作为 下一代模型，用于识别未来AUD症状的实验室预测因子。

Project Summary/Abstract The proposed project is a new submission by a New and Early Stage Investigator for an R01 (Funding Opportunity Announcement PAR-16-260). The vast majority of alcohol use takes place in social settings, yet nearly all human experimental research has administered alcohol to individuals in isolation. This research setting dampens reports of alcohol stimulation, increased positive affect, and decreased negative affect, and it makes it impossible to measure many of the subjectively pleasant social effects of alcohol that confer increased risk for alcohol use disorder (AUD) (e.g., increased sociability, decreased social anxiety). Notably, to date, laboratory subjective responses to alcohol (SRA) in isolation have accounted for between just 4% and 6% of the variance in future AUD symptoms. The proposed study will be the first to examine the effects of alcohol in social groups across a number of domains hypothesized to mediate alcohol use, and to test whether these responses can better predict the development of AUD symptoms. Further, this study will be the first to examine intermediate real-world drinking experiences using ecological momentary assessment (EMA) methods in order to evaluate how lab-based SRA translate to risk processes outside of the laboratory. Three-hundred-eighty-four heavy drinkers (50% female; aged 21-25) will be assembled into 128 three- person groups. All members of each group will drink over 36-min a moderate dose of alcohol (males: 0.82 g/kg; females: 0.74 g/kg) or a placebo beverage; SRA and social reward (e.g., social bonding) will be assessed using a broad range of measures across multiple response systems (e.g., self-reports, observational measures of smiling and speech patterns). Drinking behavior, SRA, and acute alcohol- related problems will be assessed in daily life during three subsequent EMA bursts, and AUD symptoms will be assessed at baseline and at 12-month follow-up. We predict that participants drinking alcohol will experience more stimulation/positive affect, craving, and social reward (e.g., social bonding) and less sedation, negative affect, and social discomfort on the ascending limb of the blood alcohol curve, measured across multiple response systems, than those drinking placebo. Further, we predict that these lab-based SRA and social reward indices will be clinically meaningful—that is, we expect that they will prospectively predict SRA, heavier alcohol use, and more acute alcohol-related problems in daily life, and more AUD symptoms at 12-month follow-up. Finally, we predict that SRA in daily life will mediate the link between laboratory SRA and AUD symptoms. We will also test whether individuals at risk for AUD (e.g., due to personality, genetics) are especially sensitive to alcohol's effects in the lab and in daily life and whether this predicts heavier alcohol use and the development of more AUD symptoms over time. This work, by developing a laboratory social drinking paradigm that predicts real-world alcohol responses and AUD risk, can serve as the next generation model for identifying lab-based predictors for future AUD symptoms.