Child Health Research Career Development Award (K1-Renewal Yrs 31-35)

辛辛那提儿童医院医疗中心（CCHMC）正在提交一份申请， 儿童健康研究职业发展奖（CHRCDA/K12）。这个非常成功的 CCHMC的计划已经完成了31年的成功指导医生科学家谁离开我们的 该计划定位良好，以促进儿科研究的转型变化。这是我们第六次续约 申请，我们庆祝59 CHCRDA学者谁已经实现了累计$6.29亿美国国立卫生研究院赠款 资助并发表了4000多篇研究论文。我们的学者已经成为最高领导者 在儿科研究中，许多人担任主要学术职务，我们的21名学者担任部门 儿科主任或系主任。自2017年我们最后一次提交以来，我们的研究能力 CCHMC的基础设施继续扩大，增加了从事基础教育的优秀新教师。 遗传学、免疫学、基因调控、生物信息学、罕见病等领域的研究。这 扩大的师资基础为年轻的儿科医生科学家提供了杰出的导师选择。在这 更新，我们提出了33名有成就的教师与成熟和资金充足的研究 计划，特别注重基础科学和技术创新的优势， CHRCDA学者的主要导师或共同导师。我们提出了四个具体目标， 通过多个周期成功完成该计划：确定顶尖的新学者候选人（目标1）;提供 优秀的指导环境和课程（目标2）;通过以下方式支持学者发展 接触相关的尖端技术（目标3）;以及加强新入职教师的多样性 研究密集型职业（目标4）。我们的计划在本周期推出三项新的有针对性的创新： 制定统一的机构支助职业发展方案（普罗克特预科奖学金）， CHRCDA医生-科学家早期职业发展奖学金计划;技术创新 我们的学者计划;以及一系列增强我们的多样性努力，包括任命 新的CHRCDA多样性和包容性主任。CCHMC的CHRCDA计划已经成熟， 其31年的历史，成为一个高度互动，协作，功能社区，包括更新 执行委员会，外部顾问，内部顾问和CHRCDA教师导师，所有这些人 完全致力于未来几代独立的医学科学家的成功，他们是领导者 在儿科医学中。

Cincinnati Children’s Hospital Medical Center (CCHMC) is submitting an application for the competitive renewal of its Child Health Research Career Development Award (CHRCDA/K12). This highly successful program at CCHMC has completed 31 years of successful mentoring of physician scientists who leave our program well positioned to catalyze transformational changes in pediatric research. In this, our sixth renewal application, we celebrate the 59 CHCRDA Scholars who have achieved $629M in cumulative NIH grant funding and published more than 4000 research papers. Our Scholars have advanced to become top leaders in pediatric research, many holding major academic positions, with 21 of our Scholars serving as division directors or department chairs in pediatrics. Since our last submission in 2017, the capacity of our research infrastructure at CCHMC has continued to expand, with additions of outstanding new faculty engaged in basic research in genetics, immunology, gene regulation, bioinformatics, rare diseases, and other areas. This expanded faculty base provides outstanding mentor choices for young pediatric physician-scientists. In this renewal, we are proposing 33 accomplished faculty members with mature and well-funded research programs, with a particular focus on strengths in the basic sciences and technological innovation, to serve as primary mentors or co-mentors for the CHRCDA Scholars. We propose four Specific Aims that have been successful for this program through multiple cycles: Identifying top new Scholar candidates (Aim 1); Providing an outstanding mentoring environment and curriculum (Aim 2); Supporting Scholar development through exposure to relevant cutting-edge technologies (Aim 3); and Enhancing the diversity of new faculty entering research-intensive careers (Aim 4). Our program is introducing three new Targeted Innovations this cycle: Formation of a united institutionally-supported career development program (Proctor pre-K Scholar) and CHRCDA Scholar program for physician-scientist early career development; a Technology Innovation Program for our Scholars; and a series of enhancements to our diversity efforts including the appointment of a new CHRCDA Director of Diversity and Inclusion. The CHRCDA program at CCHMC has matured during its 31 years history into a highly interactive, collaborative, functional community, including the renewed Executive Committee, External Advisors, Internal Advisors, and the CHRCDA Faculty Mentors, all of whom are fully committed to the success of future generations of independent physician-scientists who are leaders in pediatric medicine.