Advanced Training at the Interface of Engineering and Oral-Craniofacial Sciences

口腔疾病和头面部复合体中的疾病不成比例地和破坏性地折磨着易感性 人口，特别是贫困家庭和医疗或身体受损的人。小说 工程方法，如果利用得当，可以产生新的范式来揭示疾病的机制，新的 减轻疾病的战略，以及负担得起的/个性化的龋齿治疗的新方法， 牙周病和口腔癌。为了实现这一愿景，学术研究约束牙医科学家必须 精通工程概念，工程师必须受过口腔和颅面科学方面的教育 需求；所有人都必须意识到复杂的临床和监管环境。为了解决这一迫切需要，我们 建议在宾夕法尼亚大学牙医学院和宾夕法尼亚大学牙医学院开展多学科培训计划 工程与应用科学(SEA)专注于培训牙医-科学家和工程师 致力于研究精密口腔健康和医疗保健创新的学术生涯。博士后 学员将采用工程和计算科学前沿的前沿方法 借鉴方法，推进口腔生物被膜微生物群、宿主免疫和组织再生领域 包括人工智能、机器人、纳米技术和材料科学，意识到发展 安全地将新方法带给患者的障碍和要求。学员将参与互动和 通过共同指导，通过密集的指导研究获得量身定制的学术经验(每人一名顾问 学校)，以及与至少包括一名牙科临床医生的职业指导委员会(CMC)的互动。 共同导师和CMC成员将从项目学院的26名教师中挑选出来，这些教师包括 多学科和转化性研究的重要指导记录。培训内容包括：(1) 牙科实习生工程基础和工程实习生口腔颅面生物学原理， 为配合他们的研究项目和学术需要而量身定做，(2)临床研究和监管事务，(3) 科学严谨性和可重复性原则，(4)科学写作和(5)关于专业和 职业发展。学员将参与学术和行业互动、期刊俱乐部、研讨会 演讲，并参加AADR/IADR活动。培训将在F/K奖项申请中达到顶峰 专注于在牙科工程界面促进口腔健康。牛津大学的申请者群体 宾夕法尼亚州非常强大和多样化，我们预计能够吸引优秀的 候选人。此外，通过与ADA、AADR/IADR和为少数族裔服务的牙科学校建立伙伴关系，我们将 使我们的候选人人才库多样化。我们计划每年招收4名实习生。重要的是，这一努力将是 在pdm和SEA之间建立了一个新的校际中心，资金共享。拟议的计划， 宾夕法尼亚大学独有的，在紧凑的校园内利用一流的研究和培训环境， 这两所学校的资源通过宾夕法尼亚大学新成立的创新和精密牙科中心统一起来。

Oral diseases and disorders in the craniofacial complex disproportionally and devastatingly afflict susceptible populations, particularly impoverished families and medically or physically compromised persons. Novel engineering approaches, properly leveraged, can yield new paradigms to reveal disease mechanism, new strategies for disease mitigation, and new approaches for affordable/personalized therapies for dental caries, periodontal diseases, and oral cancer. To achieve this vision, academic research bound dentist-scientists must be adept in engineering concepts and engineers must be educated in oral and craniofacial sciences and needs; all must be aware of the complex clinical and regulatory landscapes. To address this urgent need, we propose a multidisciplinary training program in Penn’s School of Dental Medicine (PDM) and School of Engineering & Applied Sciences (SEAS) focused on training dentist-scientists and engineers for academic careers dedicated to research in precision oral health and healthcare innovation. Postdoctoral trainees will adopt cutting-edge approaches at the forefront of engineering and computational sciences to advance the fields of oral biofilm microbiome, host immunity and tissue regeneration, drawing on approaches including artificial intelligence, robotics, nanotechnology, and materials sciences, aware of developmental hurdles and requirements to safely bring new approaches to patients. Trainees will engage in interactive and tailored academic experiences with intensive mentored research via co-mentoring (one advisor from each school), and interaction with a career mentoring committee (CMC) that includes at least one dental clinician. Co-mentors and CMC members will be drawn from the Program Faculty of 26 faculty in PDM and SEAS with significant records of mentorship of multidisciplinary and translational research. Training will include: (1) engineering fundamentals for dental trainees and oral & craniofacial biology principles for engineering trainees, tailored to match their research project and academic needs, (2) clinical research and regulatory affairs, (3) principles of scientific rigor and reproducibility, (4) scientific writing and (5) workshops on professional and career development. Trainees will engage in academic and industry interactions, journal club, give symposia presentations, and participate in AADR/IADR activities. Training will culminate in F/K award applications focused on advancing oral health at the dental-engineering interface. The applicant pool at the University of Pennsylvania is exceptionally strong and diverse, and we anticipate being able to attract outstanding candidates. Furthermore, via partnerships with ADA, AADR/IADR and minority-serving dental schools, we will diversify our candidate pool. We plan to enroll 4 trainees per year. Importantly, this effort will be an element of a newly formed inter-school center between PDM and SEAS with shared funding. The proposed program, unique to Penn, leverages a superb research and training environment within a compact campus where resources for both schools are united through Penn’s new Center for Innovation and Precision Dentistry.