Administrative Core

摘要 行政核心，核心A的主要目标是提供科学的、行政的 以及对PDTC方案的三个项目和三个核心的财务监督和管理 在德克萨斯大学MD安德森癌症中心(UTMDACC；UTPDTC)，以及 与德克萨斯大学西南医学中心(UTSW)的联盟。这包括 赠款管理；科学和财政支持；定期科学和行政审查， 外联和信息传播、人事管理和协调会议。 核心A将在促进有价值的互动方面发挥重要的统一作用，而不仅仅是 UTPDCT项目和核心领导人，但也有来自其他三个PDTC的调查人员资助 NCI和NCI官员。这一核心将：a)指导整体科学素质和管理 UTPDTC的管理；B)确保有效沟通和整合 研究项目(1-3)，与UTMDACC和UTSW的联合体，生物信息学(核心B)，PDX (核心C)、试点项目和跨网络活动(核心D)核心；C)促进 与NCI科研人员沟通，并与PDXNet、PDXNet数据进行协作互动 公共和协调中心(PDCCC)和NCI患者衍生模型存储库 (PDMR)弗雷德里克国家癌症研究实验室(FNLCR)；D)监测和 确保UTPDTC与所有具体的NCI法规和 必要的报告要求；e)协调数据质量控制和保证问题；f) 监督支出并维护预算信息；g)组织所有必要的会议， 包括指导和内部咨询委员会(UTMDACC)、定期科学会议、 讲座、座谈会和出席PDXNet指导委员会年度会议(NCI)； 遵守美国国立卫生研究院关于共享独特研究资源的拨款政策；i)协调 并促进科学争端的解决。

Abstract The primary objectives of the Administrative Core, Core A, are to provide scientific, administrative and fiscal oversight and management to the three projects and three cores of the PDTC program at the University of Texas MD Anderson Cancer Center (UTMDACC; UTPDTC), and the consortium with the University of Texas South Western Medical Center (UTSW). This includes grant management; scientific and fiscal support, periodic scientific and administrative reviews, outreach and information dissemination, personnel management, and coordination of meetings. Core A will play a major unifying role in stimulating valuable interactions not only between UTPDCT project and core leaders, but also with investigators from the other three PDTCs funded by NCI and NCI officials. This core will: A) Direct the overall scientific quality and administrative management of the UTPDTC; B) Ensure effective communication and integration between research projects (1-3), the consortium with UTMDACC and UTSW, Bioinformatics (Core B), PDX (Core C), and Pilot Projects and Trans-Network Activities (Core D) cores; C) Facilitate communication with NCI scientific staff and collaborative interactions with PDXNet, PDXNet Data Commons and Coordinating Center (PDCCC), and NCI Patient-Derived Models Repository (PDMR) at the Frederick National Laboratory for Cancer Research (FNLCR); D) Monitor and ensure the overall compliance of UTPDTC in conjunction with all specific NCI regulations and necessary reporting requirements; E) Coordinate data quality control and assurance issues; F) Oversee expenditures and maintain budget information; G) Organize all necessary meetings, including the Steering and Internal Advisory Committees (UTMDACC), regular scientific meetings, lectures, symposia, and attendance to the annual PDXNet Steering Committee meeting (NCI); H) Adhere to the NIH Grant Policy on Sharing of Unique Research Resources; and I) Coordinate and facilitate resolution of scientific disputes.